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Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype
Author(s) -
Baril AndréeAnn,
Beiser Alexa S.,
Sanchez Erlan,
Mysliwiec Vincent,
Redline Susan,
Gottlieb Daniel J.,
O'Connor George T.,
Gonzales Mitzi M.,
Himali Dibya,
Seshadri Sudha,
Himali Jayandra J.,
Pase Matthew P.
Publication year - 2022
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.12405
Subject(s) - insomnia , dementia , cognition , effects of sleep deprivation on cognitive performance , apolipoprotein e , recall , neuropsychology , psychology , medicine , clinical psychology , psychiatry , disease , cognitive psychology
Abstract Introduction We evaluated whether insomnia symptom severity was associated with cognitive function, and whether this relationship was modified by biomarkers associated with Alzheimer's disease risk. Methods We examined insomnia symptoms and neuropsychological performance 3.4 years later in 511 dementia‐free Framingham Heart Study participants (62.65 ± 8.7 years, 50.9% male). Additionally, we explored insomnia symptoms combined with self‐reported short habitual sleep duration and effect modification by apolipoprotein E ( APOE ) ε4 allele status. Results More severe insomnia symptoms were associated with lower performance on global cognition, and immediate and delayed Logical Memory recall, especially when insomnia symptoms were combined with short sleep duration. The association between insomnia symptoms and poorer memory recall was more pronounced in APOE ε4 allele carriers. Discussion Insomnia symptom severity was associated with worse subsequent global cognitive and memory performance, which was especially apparent in APOE ε4 allele carriers, suggesting that poor sleep might be particularly detrimental when the brain is already vulnerable to neurodegeneration.