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Body mass index in early adulthood and dementia in late life: Findings from a pooled cohort
Author(s) -
Zeki Al Hazzouri Adina,
Vittinghoff Eric,
Hoang Tina,
Golden Sherita H.,
Fitzpatrick Annette L.,
Zhang Adina,
Grasset Leslie,
Yaffe Kristine
Publication year - 2021
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.12367
Subject(s) - dementia , body mass index , medicine , overweight , odds ratio , cohort , obesity , confidence interval , gerontology , demography , cohort study , logistic regression , incidence (geometry) , early adulthood , young adult , disease , physics , sociology , optics
To examine the independent association of body mass index (BMI) in early adulthood with dementia incidence among men and women. Methods We studied 5104 older adults from the Cardiovascular Health Study (CHS) and the Health, Aging, and Body Composition (Health ABC) study. We imputed early adulthood and midlife BMI using a pooled parent cohort with complete adult lifespan coverage and previously established methods. Dementia was ascertained using criteria such as neuropsychological test battery, medical records, and dementia‐related drug use. Pooled logistic regression (PLR) models were used. Results Compared to women with normal BMI in early adulthood, the odds of dementia were higher among both overweight (odds ratio [OR] = 1.8; 95% confidence interval [CI] = 1.31 to 2.54) and obese (OR = 2.45; 95% CI = 1.47 to 4.06) women, independent of mid‐ and late‐life BMI. Similar relationship was observed in men. Conclusions With the growing obesity epidemic among US adults, efforts aimed at reducing dementia may need to begin obesity prevention and treatment early in the life course.