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Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype
Author(s) -
Guo Jing,
Brickman Adam M.,
Manly Jennifer J.,
Reitz Christiane,
Schupf Nicole,
Mayeux Richard P.,
Gu Yian
Publication year - 2021
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.12359
Subject(s) - dementia , hazard ratio , apolipoprotein e , medicine , proportional hazards model , confidence interval , gerontology , genotype , population , demography , environmental health , genetics , disease , biology , sociology , gene
There is limited and inconsistent reporting on the association between Life's Simple 7 (LS7) and dementia in the elderly population. Methods Based on the Washington Heights‐Inwood Columbia Aging Project (WHICAP), LS7 scores were estimated to assess cardiovascular health status. Associations between LS7 scores and incident dementia were investigated by Cox proportional hazards models. Results Among 1987 subjects, 291 incident cases of dementia were identified over a median follow‐up of 5.84 years. Compared with subjects in the poor cardiovascular health group (scores 0 to 5), those in intermediate (6 to 9) and optimal (10 to 14) groups had lower dementia risk, with the hazard ratio (HR; 95% confidence interval) being 0.74 (0.54 to 1.00) and 0.59 (0.38 to 0.91), respectively. These results were significant in apolipoprotein E genotype ε4 ( APOE ε4) allele non‐carriers but not in carriers. Discussion Higher LS7 scores are protective for dementia, especially among the APOE ε4 noncarriers.