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Reduced synchrony in alpha oscillations during life predicts post mortem neurofibrillary tangle density in early‐onset and atypical Alzheimer's disease
Author(s) -
Ranasinghe Kamalini G.,
Petersen Cathrine,
Kudo Kiwamu,
Mizuiri Danielle,
Rankin Katherine P.,
Rabinovici Gil D.,
GornoTempini Maria Luisa,
Seeley William W.,
Spina Salvatore,
Miller Bruce L.,
Vossel Keith,
Grinberg Lea T.,
Nagarajan Srikantan S.
Publication year - 2021
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.12349
Subject(s) - neurofibrillary tangle , subiculum , neuroscience , alzheimer's disease , pathological , hippocampal formation , alpha (finance) , tangle , neuropathology , psychology , middle frontal gyrus , pathology , medicine , disease , senile plaques , dentate gyrus , functional magnetic resonance imaging , mathematics , pure mathematics , clinical psychology , construct validity , psychometrics
Neurophysiological manifestations selectively associated with amyloid beta and tau depositions in Alzheimer's disease (AD) are useful network biomarkers to identify peptide specific pathological processes. The objective of this study was to validate the associations between reduced neuronal synchrony within alpha oscillations and neurofibrillary tangle (NFT) density in autopsy examination, in patients with AD. Methods In a well‐characterized clinicopathological cohort of AD patients (n = 13), we quantified neuronal synchrony within alpha (8–12 Hz) and delta‐theta (2–8 Hz) oscillations, using magnetoencephalography during the disease course, within six selected neocortical and hippocampal regions, including angular gyrus, superior temporal gurus, middle frontal gyrus, primary motor cortex, CA1, and subiculum, and correlated these with regional NFT density quantified at histopathological examination. Results Abnormal synchrony in alpha, but not in delta‐theta, significantly predicted the NFT density at post mortem neuropathological examination. Discussion Reduced alpha synchrony is a sensitive neurophysiological index associated with pathological tau, and a potential network biomarker for clinical trials, to gauge the extent of network dysfunction and the degree of rescue in treatments targeting tau pathways in AD.