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Association of cardiovascular risk burden with risk of dementia and brain pathologies: A population‐based cohort study
Author(s) -
Song Ruixue,
Pan KuanYu,
Xu Hui,
Qi Xiuying,
Buchman Aron S.,
Bennett David A.,
Xu Weili
Publication year - 2021
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.12343
Subject(s) - dementia , medicine , framingham heart study , hazard ratio , odds ratio , vascular dementia , framingham risk score , cohort , cohort study , confidence interval , alzheimer's disease , disease
The impact of cardiovascular risk burden on brain pathologies remains unclear. We aimed to examine the association of the Framingham General Cardiovascular Risk Score (FGCRS) with dementia risk, and brain pathologies. Methods Within the Rush Memory and Aging Project, 1588 dementia‐free participants were assessed on FGCRS at baseline and followed up to 21 years. During the follow‐up, 621 participants died and underwent autopsies. Results The multi‐adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) of FGCRS were 1.03 (1.00–1.07) for dementia and 1.04 (1.01–1.07) for Alzheimer's disease (AD) dementia. Further, a higher FGCRS was associated with higher gross chronic cerebral infarctions (odds ratio [OR] 1.08, 95% CI 1.02–1.14), cerebral atherosclerosis (OR 1.10, 95% CI 1.03–1.17), and global AD pathology (OR 1.06, 95% CI 1.01–1.12). Conclusions A higher FGCRS is associated with an increased risk of dementia and AD dementia. Both vascular and AD pathologies in the brain may underlie this association.