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Characterization of dementia with Lewy bodies (DLB) and mild cognitive impairment using the Lewy body dementia module (LBD‐MOD)
Author(s) -
Galvin James E.,
Chrisphonte Stephanie,
Cohen Iris,
Greenfield Keri K.,
Kleiman Michael J.,
Moore Claudia,
Riccio Mary Lou,
Rosenfeld Amie,
Shkolnik Niurka,
Walker Marcia,
Chang LunChing,
Tolea Magdalena I.
Publication year - 2021
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.12334
Subject(s) - dementia with lewy bodies , dementia , lewy body , audiology , psychology , parkinson's disease , lewy body disease , apathy , cognition , rem sleep behavior disorder , cognitive impairment , physical medicine and rehabilitation , disease , medicine , psychiatry , pathology
The National Institute on Aging Alzheimer's Disease Research Center program added the Lewy body dementia module (LBD‐MOD) to the Uniform Data Set to facilitate LBD characterization and distinguish dementia with Lewy bodies (DLB) from Alzheimer's disease (AD). We tested the performance of the LBD‐MOD. Methods The LBD‐MOD was completed in a single‐site study in 342 participants: 53 controls, 78 AD, and 110 DLB; 79 mild cognitive impairment due to AD (MCI‐AD); and 22 MCI‐DLB. Results DLB differed from AD in extrapyramidal symptoms, hallucinations, apathy, autonomic features, REM sleep behaviors, daytime sleepiness, cognitive fluctuations, timed attention tasks, and visual perception. MCI‐DLB differed from MCI‐AD in extrapyramidal features, mood, autonomic features, fluctuations, timed attention tasks, and visual perception. Descriptive data on LBD‐MOD measures are provided for reference. Discussion The LBD‐MOD provided excellent characterization of core and supportive features to differentiate DLB from AD and healthy controls while also characterizing features of MCI‐DLB.