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Quantifying progression in primary progressive aphasia with structural neuroimaging
Author(s) -
Lombardi Jolina,
Mayer Benjamin,
Semler Elisa,
AnderlStraub Sarah,
Uttner Ingo,
Kassubek Jan,
DiehlSchmid Janine,
Danek Adrian,
Levin Johannes,
Fassbender Klaus,
Fliessbach Klaus,
Schneider Anja,
Huppertz HansJürgen,
Jahn Holger,
Volk Alexander,
Kornhuber Johannes,
Landwehrmeyer Bernhard,
Lauer Martin,
Prudlo Johannes,
Wiltfang Jens,
Schroeter Matthias L.,
Ludolph Albert,
Otto Markus
Publication year - 2021
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.12323
Subject(s) - primary progressive aphasia , atrophy , neuroimaging , temporal lobe , medicine , aphasia , magnetic resonance imaging , frontal lobe , neuroscience , pathology , disease , psychology , frontotemporal dementia , radiology , dementia , psychiatry , epilepsy
Abstract Introduction The term primary progressive aphasia (PPA) sums up the non‐fluent (nfv), the semantic (sv), and the logopenic (lv) variant. Up to now, there is only limited data available concerning magnetic resonance imaging volumetry to monitor disease progression. Methods Structural brain imaging and an extensive assessment were applied at baseline and up to 4‐year(s) follow‐up in 269 participants. With automated atlas‐based volumetry 56 brain regions were assessed. Atrophy progression served to calculate sample sizes for therapeutic trials. Results At baseline highest atrophy appeared in parts of the left frontal lobe for nfvPPA (–17%) and of the left temporal lobe for svPPA (–34%) and lvPPA (–24%). Severest progression within 1‐year follow‐up occurred in the basal ganglia in nfvPPA (–7%), in the hippocampus/amygdala in svPPA (–9%), and in (medial) temporal regions in lvPPA (–6%). Conclusion PPA presents as a left‐dominant, mostly gray matter sensitive disease with considerable atrophy at baseline that proceeds variant‐specific.