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Measures of resting state EEG rhythms for clinical trials in Alzheimer's disease: Recommendations of an expert panel
Author(s) -
Babiloni Claudio,
Arakaki Xianghong,
Azami Hamed,
Bennys Karim,
Blinowska Katarzyna,
Bonanni Laura,
Bujan Ana,
Carrillo Maria C.,
Cichocki Andrzej,
FrutosLucas Jaisalmer,
Del Percio Claudio,
Dubois Bruno,
Edelmayer Rebecca,
Egan Gary,
Epelbaum Stephane,
Escudero Javier,
Evans Alan,
Farina Francesca,
Fargo Keith,
Fernández Alberto,
Ferri Raffaele,
Frisoni Giovanni,
Hampel Harald,
Harrington Michael G.,
Jelic Vesna,
Jeong Jaeseung,
Jiang Yang,
Kaminski Maciej,
Kavcic Voyko,
Kilborn Kerry,
Kumar Sanjeev,
Lam Alice,
Lim Lew,
Lizio Roberta,
Lopez David,
Lopez Susanna,
Lucey Brendan,
Maestú Fernando,
McGeown William J.,
McKeith Ian,
Moretti Davide Vito,
Nobili Flavio,
Noce Giuseppe,
Olichney John,
Onofrj Marco,
Osorio Ricardo,
ParraRodriguez Mario,
Rajji Tarek,
Ritter Petra,
Soricelli Andrea,
Stocchi Fabrizio,
Tarnanas Ioannis,
Taylor John Paul,
Teipel Stefan,
Tucci Federico,
ValdesSosa Mitchell,
ValdesSosa Pedro,
Weiergräber Marco,
Yener Gorsev,
Guntekin Bahar
Publication year - 2021
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.12311
Subject(s) - electroencephalography , beta rhythm , dementia , disease , clinical trial , rhythm , medicine , resting state fmri , psychology , neuroscience , physical medicine and rehabilitation
The Electrophysiology Professional Interest Area (EPIA) and Global Brain Consortium endorsed recommendations on candidate electroencephalography (EEG) measures for Alzheimer's disease (AD) clinical trials. The Panel reviewed the field literature. As most consistent findings, AD patients with mild cognitive impairment and dementia showed abnormalities in peak frequency, power, and “interrelatedness” at posterior alpha (8‐12 Hz) and widespread delta (< 4 Hz) and theta (4‐8 Hz) rhythms in relation to disease progression and interventions. The following consensus statements were subscribed: (1) Standardization of instructions to patients, resting state EEG (rsEEG) recording methods, and selection of artifact‐free rsEEG periods are needed; (2) power density and “interrelatedness” rsEEG measures (e.g., directed transfer function, phase lag index, linear lagged connectivity, etc.) at delta, theta, and alpha frequency bands may be use for stratification of AD patients and monitoring of disease progression and intervention; and (3) international multisectoral initiatives are mandatory for regulatory purposes.