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Investigating the association between cancer and the risk of dementia: Results from the Memento cohort
Author(s) -
Chamberlain Jonviea D.,
Rouanet Anaïs,
Dubois Bruno,
Pasquier Florence,
Ha Olivier,
Gabelle Audrey,
Ceccaldi Mathieu,
KrolakSalmon Pierre,
Béjot Yannick,
Godefroy Olivier,
Wallon David,
Gentric Armelle,
Chêne Geneviève,
Dufouil Carole
Publication year - 2021
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.12308
Subject(s) - dementia , hazard ratio , medicine , cohort , confounding , cohort study , cancer , confidence interval , proportional hazards model , gerontology , disease
Studies on the association of cancer and risk of dementia are inconclusive due to result heterogeneity and concerns of survivor bias and unmeasured confounding. Methods This study uses data from the Memento cohort, a French multicenter cohort following persons with either mild or isolated cognitive complaints for a median of 5 years. Illness‐death models (IDMs) were used to estimate transition‐specific hazard ratios (HRs) and 95% confidence intervals (CIs) for incident cancer in relation to dementia from time since study entry. Results The analytical sample (N = 2258) excluded 65 individuals without follow‐up information. At the end of follow‐up, 286 individuals were diagnosed with dementia, 166 with incident cancer, and 95 died. Incident cancer was associated with a reduced risk of dementia (HR = 0.58, 95% CI = 0.35‐0.97), with a corresponding E‐value of 2.84 (lower CI = 1.21). Discussion This study supports a protective relationship between incident cancer and dementia, encouraging further investigations to understand potential underlying mechanisms.