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Circulating metabolites are associated with brain atrophy and white matter hyperintensities
Author(s) -
Leeuw Francisca A.,
KaramujićČomić Hata,
Tijms Betty M.,
Peeters Carel F.W.,
Kester Maartje I.,
Scheltens Philip,
Ahmad Shahzad,
Vojinovic Dina,
Adams Hieab H.H.,
Hankemeier Thomas,
Bos Daniel,
Lugt Aad,
Vernooij Meike W.,
Ikram M. Arfan,
Amin Najaf,
Barkhof Frederik,
Teunissen Charlotte E.,
Duijn Cornelia M.,
Flier Wiesje M.
Publication year - 2021
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.12180
Subject(s) - atrophy , hyperintensity , white matter , hippocampal formation , magnetic resonance imaging , medicine , psychology , endocrinology , pathology , radiology
Our aim was to study whether systemic metabolites are associated with magnetic resonance imaging (MRI) measures of brain and hippocampal atrophy and white matter hyperintensities (WMH). Methods We studied associations of 143 plasma‐based metabolites with MRI measures of brain and hippocampal atrophy and WMH in three independent cohorts (n = 3962). We meta‐analyzed the results of linear regression analyses to determine the association of metabolites with MRI measures. Results Higher glucose levels and lower levels of three small high density lipoprotein (HDL) particles were associated with brain atrophy. Higher glucose levels were associated with WMH. Discussion Glucose levels were associated with brain atrophy and WMH, and small HDL particle levels were associated with brain atrophy. Circulating metabolites may aid in developing future intervention trials.