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Retinal imaging in Alzheimer's and neurodegenerative diseases
Author(s) -
Snyder Peter J.,
Alber Jessica,
Alt Clemens,
Bain Lisa J.,
Bouma Brett E.,
Bouwman Femke H.,
DeBuc Delia Cabrera,
Campbell Melanie C.W.,
Carrillo Maria C.,
Chew Emily Y.,
Cordeiro M. Francesca,
Dueñas Michael R.,
Fernández Brian M.,
KoronyoHamaoui Maya,
La Morgia Chiara,
Carare Roxana O’,
Sadda Srinivas R.,
Wijngaarden Peter,
Snyder Heather M.
Publication year - 2021
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.12179
Subject(s) - context (archaeology) , neuroscience , dementia , modalities , disease , retinal , alzheimer's disease , medicine , psychology , pathology , ophthalmology , biology , paleontology , social science , sociology
In the last 20 years, research focused on developing retinal imaging as a source of potential biomarkers for Alzheimer's disease and other neurodegenerative diseases, has increased significantly. The Alzheimer's Association and the Alzheimer's & Dementia: Diagnosis, Assessment, Disease Monitoring editorial team (companion journal to Alzheimer's & Dementia ) convened an interdisciplinary discussion in 2019 to identify a path to expedite the development of retinal biomarkers capable of identifying biological changes associated with AD, and for tracking progression of disease severity over time. As different retinal imaging modalities provide different types of structural and/or functional information, the discussion reflected on these modalities and their respective strengths and weaknesses. Discussion further focused on the importance of defining the context of use to help guide the development of retinal biomarkers. Moving from research to context of use, and ultimately to clinical evaluation, this article outlines ongoing retinal imaging research today in Alzheimer's and other brain diseases, including a discussion of future directions for this area of study.