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Lifestyle, multi‐omics features, and preclinical dementia among Chinese: The Taizhou Imaging Study
Author(s) -
Jiang Yanfeng,
Cui Mei,
Tian Weizhong,
Zhu Sibo,
Chen Jinhua,
Suo Chen,
Liu Zhenqiu,
Lu Ming,
Xu Kelin,
Fan Min,
Wang Jiucun,
Dong Qiang,
Ye Weimin,
Jin Li,
Chen Xingdong
Publication year - 2021
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.12171
Subject(s) - dementia , sociocultural evolution , neuroimaging , ethnic group , gerontology , china , medicine , epidemiology , chinese population , cohort , disease , psychiatry , pathology , geography , political science , biology , archaeology , law , biochemistry , genotype , gene
China has the largest number of patients with dementia in the world. However, dementia in the Chinese population is still poorly understood and under‐researched. Given the differences in genetic, demographic, sociocultural, lifestyle, and health profiles among Chinese and other ethnic/racial groups, it is crucial to build appropriate infrastructure for long‐term longitudinal studies to advance Chinese cognitive aging and dementia research. We initiated a community‐based prospective cohort—the Taizhou Imaging Study (TIS)—to accelerate the understanding of dementia and cerebrovascular diseases in Chinese. This article presents the rationale, aims, study design, and organization of TIS. In addition, we described some examples of the types of studies such a resource might support. The TIS provides a new framework for facilitating Chinese dementia research, encompassing invaluable resources including detailed epidemiological, sociocultural, neuroimaging, and omics data.