Premium
Prediction of dementia of Alzheimer type by different types of subjective cognitive decline
Author(s) -
Jessen Frank,
Kleineidam Luca,
Wolfsgruber Steffen,
Bickel Horst,
Brettschneider Christian,
Fuchs Angela,
Kaduszkiewicz Hanna,
König HansHelmut,
Mallon Tina,
Mamone Silke,
Pabst Alexander,
Pentzek Michael,
Roehr Susanne,
Weeg Dagmar,
Jochen Werle,
Weyerer Siegfried,
Wiese Birgitt,
Maier Wolfgang,
Scherer Martin,
RiedelHeller Steffi,
Wagner Michael
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.12163
Subject(s) - dementia , cognitive decline , medicine , alzheimer's disease , cognition , gerontology , cognitive impairment , population , psychology , psychiatry , disease , environmental health
Subjective cognitive decline (SCD) is a risk condition for dementia, including dementia of Alzheimer type (DAT). Methods We report sensitivity, specificity, positive and negative predictive values (PPV, NPV) for conversion to all‐cause dementia, and DAT in different SCD types (decline in memory, assocated worries, longitudinal consitency, of the AgeCoDe study (n = 2.402, 12 years follow‐up). Results 82.7% of those converting to any dementia and 84.4% of those converting with DAT at follow‐up, reported memory decline and fulfilled criteria of SCD at least at one time point before. SCD with worries at two consecutive time points showed a specificity of 92.2% for any dementia and also for DAT as well as a PPV of 44.3% for any dementia and of 36.9% for DAT at follow‐up at the expense of low sensitivity. Discussion Different SCD subtypes were either sensitive or specific for future all‐cause dementia and DAT in cognitively unimpaired individuals. Modest PPV of the most specific SCD subtypes were achieved in this low prevalence population.