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Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop
Author(s) -
Zlokovic Berislav V.,
Gottesman Rebecca F.,
Bernstein Kenneth E.,
Seshadri Sudha,
McKee Ann,
Snyder Heather,
Greenberg Steven M.,
Yaffe Kristine,
Schaffer Chris B.,
Yuan Chun,
Hughes Timothy M.,
Daemen Mat J.,
Williamson Jeff D.,
González Hector M.,
Schneider Julie,
Wellington Cheryl L.,
Katusic Zvonimir S.,
Stoeckel Luke,
Koenig James I.,
Corriveau Roderick A.,
Fine Lawrence,
Galis Zorina S.,
Reis Jared,
Wright Jacqueline D.,
Chen Jue
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.12157
Subject(s) - dementia , medicine , disease , stroke (engine) , intensive care medicine , vascular dementia , cognitive decline , cognition , gerontology , psychiatry , psychology , pathology , mechanical engineering , engineering
Vascular contributions to cognitive impairment and dementia (VCID) are characterized by the aging neurovascular unit being confronted with and failing to cope with biological insults due to systemic and cerebral vascular disease, proteinopathy including Alzheimer's biology, metabolic disease, or immune response, resulting in cognitive decline. This report summarizes the discussion and recommendations from a working group convened by the National Heart, Lung, and Blood Institute and the National Institute of Neurological Disorders and Stroke to evaluate the state of the field in VCID research, identify research priorities, and foster collaborations. As discussed in this report, advances in understanding the biological mechanisms of VCID across the wide spectrum of pathologies, chronic systemic comorbidities, and other risk factors may lead to potential prevention and new treatment strategies to decrease the burden of dementia. Better understanding of the social determinants of health that affect risks for both vascular disease and VCID could provide insight into strategies to reduce racial and ethnic disparities in VCID.