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Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients
Author(s) -
Finsterwalder Sofia,
Vlegels Naomi,
Gesierich Benno,
Araque Caballero Miguel Á.,
Weaver Nick A.,
Franzmeier Nicolai,
Georgakis Marios K.,
Konieczny Marek J.,
Koek Huiberdina L.,
Karch Celeste M.,
GraffRadford Neill R.,
Salloway Stephen,
Oh Hwamee,
Allegri Ricardo F.,
Chhatwal Jasmeer P.,
Jessen Frank,
Düzel Emrah,
Dobisch Laura,
Metzger Coraline,
Peters Oliver,
Incesoy Enise I.,
Priller Josef,
Spruth Eike J.,
Schneider Anja,
Fließbach Klaus,
Buerger Katharina,
Janowitz Daniel,
Teipel Stefan J.,
Kilimann Ingo,
Laske Christoph,
Buchmann Martina,
Heneka Michael T.,
Brosseron Frederic,
Spottke Annika,
Roy Nina,
ErtlWagner Birgit,
Scheffler Klaus,
Seo Sang Won,
Kim Yeshin,
Na Duk L.,
Kim Hee Jin,
Jang Hyemin,
Ewers Michael,
Levin Johannes,
Schmidt Reinhold,
Pasternak Ofer,
Dichgans Martin,
Biessels Geert Jan,
Duering Marco
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.12150
Subject(s) - diffusion mri , voxel , memory clinic , disease , diffusion , alzheimer's disease , medicine , pathology , magnetic resonance imaging , radiology , physics , dementia , thermodynamics
Abstract Introduction Microstructural alterations as assessed by diffusion tensor imaging (DTI) are key findings in both Alzheimer's disease (AD) and small vessel disease (SVD). We determined the contribution of each of these conditions to diffusion alterations. Methods We studied six samples (N = 365 participants) covering the spectrum of AD and SVD, including genetically defined samples. We calculated diffusion measures from DTI and free water imaging. Simple linear, multivariable random forest, and voxel‐based regressions were used to evaluate associations between AD biomarkers (amyloid beta, tau), SVD imaging markers, and diffusion measures. Results SVD markers were strongly associated with diffusion measures and showed a higher contribution than AD biomarkers in multivariable analysis across all memory clinic samples. Voxel‐wise analyses between tau and diffusion measures were not significant. Discussion In memory clinic patients, the effect of SVD on diffusion alterations largely exceeds the effect of AD, supporting the value of diffusion measures as markers of SVD.