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Cortical atrophy patterns of incident MCI subtypes in the Mayo Clinic Study of Aging
Author(s) -
Machulda Mary M.,
Lundt Emily S.,
Albertson Sabrina M.,
Spychalla Anthony J.,
Schwarz Christopher G.,
Mielke Michelle M.,
Jack Clifford R.,
Kremers Walter K.,
Vemuri Prashanthi,
Knopman David S.,
Jones David T.,
Bondi Mark W.,
Petersen Ronald C.
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.12108
Subject(s) - entorhinal cortex , atrophy , cognition , psychology , dementia , neuroscience , audiology , cognitive impairment , cognitive decline , cortex (anatomy) , medicine , hippocampus , disease
We examined differences in cortical thickness in empirically derived mild cognitive impairment (MCI) subtypes in the Mayo Clinic Study of Aging. Methods We compared cortical thickness of four incident MCI subtypes (n = 192) to 1257 cognitive unimpaired individuals. Results The subtle cognitive impairment cluster had atrophy in the entorhinal and parahippocampal cortex. The amnestic, dysnomic, and dysexecutive clusters also demonstrated entorhinal cortex atrophy as well as thinning in temporal, parietal, and frontal isocortex in somewhat different patterns. Discussion We found patterns of atrophy in each of the incident MCI clusters that corresponded to their patterns of cognitive impairment. The identification of MCI subtypes based on cognitive and structural features may allow for more efficient trial and study designs. Given individuals in the subtle cognitive impairment cluster have less structural changes and cognitive decline and may represent the earliest group, this could be a unique group to target with early interventions.