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Mild behavioral impairment is associated with β‐amyloid but not tau or neurodegeneration in cognitively intact elderly individuals
Author(s) -
Lussier Firoza Z.,
Pascoal Tharick A.,
Chamoun Mira,
Therriault Joseph,
Tissot Cécile,
Savard Mélissa,
Kang Min Su,
Mathotaarachchi Sulantha,
Benedet Andrea L.,
Parsons Marlee,
Qureshi Muhammad Naveed Iqbal,
Thomas Émilie M.,
Shin Monica,
Dion LaurieAnne,
Massarweh Gassan,
Soucy JeanPaul,
Tsai IHuang,
Vitali Paolo,
Ismail Zahinoor,
RosaNeto Pedro,
Gauthier Serge
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.12007
Subject(s) - psychology , medicine , population , clinical psychology , environmental health
Mild behavioral impairment (MBI) is characterized by the emergence of neuropsychiatric symptoms in elderly persons. Here, we examine the associations between MBI and Alzheimer's disease (AD) biomarkers in asymptomatic elderly individuals. Methods Ninety‐six cognitively normal elderly individuals underwent MRI, [ 18 F]AZD4694 β‐amyloid‐PET, and [ 18 F]MK6240 tau‐PET. MBI was assessed using the MBI Checklist (MBI‐C). Pearson's correlations and voxel‐based regressions were used to evaluate the relationship between MBI‐C score and [ 18 F]AZD4694 retention, [ 18 F]MK6240 retention, and gray matter (GM) volume. Results Pearson correlations revealed a positive relationship between MBI‐C score and global and striatal [ 18 F]AZD4694 standardized uptake value ratios (SUVRs). Voxel‐based regression analyses revealed a positive correlation between MBI‐C score and [ 18 F]AZD4694 retention. No significant correlations were found between MBI‐C score and [ 18 F]MK6240 retention or GM volume. Conclusion We demonstrate for the first time a link between MBI and early AD pathology in a cognitively intact elderly population, supporting the use of the MBI‐C as a metric to enhance clinical trial enrolment.