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Analysis of the ACE‐R’s sub‐items that best differentiate healthy controls, amnestic MCI and non‐amnestic MCI
Author(s) -
de Oliveira Maira Okada,
Tres Eduardo sturzeneker,
Cassimiro Luciana,
Avolio Isabella B,
Brucki Sonia Maria Dozzi
Publication year - 2021
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.056359
Subject(s) - verbal fluency test , dementia , psychology , fluency , recall , cognition , progressive supranuclear palsy , audiology , neuropsychology , frontotemporal dementia , neuropsychological test , parkinsonism , amnesia , clinical psychology , developmental psychology , disease , medicine , psychiatry , cognitive psychology , mathematics education
Background The Addenbrooke's Cognitive Examination‐Revised (ACE‐R) is a brief yet reliable test battery that provides evaluation of six cognitive domains (orientation, attention, memory, verbal fluency, language and visuospatial ability) and widely used to measure cognition. It was developed and revised to provide a brief test sensitive to the early stages of dementia, and is also effective for differentiating the subtypes of dementia, such as Alzheimer’s disease, frontotemporal dementia, progressive supranuclear palsy, and other forms of dementia associated with parkinsonism. Our objective was to identify which sub‐items of ACE‐R could differentiate health controls, amMCI and non‐amMCI. Method Data originated from Brazilian Aging Memory Study (BRAMS).110 subjects: health controls (HC) (n=22; age 73.6±6y; schooling 14±4y; 77.2% female), amnestic MCI (amMCI) patients (n=64; age 73±6y; schooling 11±5y; 81.2% female) and non‐amnestic (non‐amnMCI) patients (n=24; age 70±7y; schooling 12±45y; 83.3% female) assessed by neurological exam and neuropsychological assessment. The Brazilian version of ACE‐R was applied as part of the cognitive assessment in all participants, but was not used to determine diagnosis. Result The following items differentiated between HC and amMCI: 3‐words recall (p=0.04 ), name/address recall ( p=0.02 ), Verbal Fluency Letter P ( p=0.01 ) and Verbal Fluency Animals ( p<0.01 ); No differences were found between HC and non‐amMCI and non‐amMCI and amMCI. Conclusion Identifying sub‐items that best differentiates groups could add more information to the clinician regarding the diagnosis and progression of the disease.