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Feasibility of short imaging protocols for [ 18 F]PI‐2620 tau‐PET in progressive supranuclear palsy
Author(s) -
Song Mengmeng,
Scheifele Maximilian,
Barthel Henryk,
van Eimeren Thilo,
Beyer Leonie,
Marek Ken,
Eckenweber Florian,
Palleis Carla,
Finze Anika,
Kaiser Lena,
Kern Maike,
Nitschmann Alexander,
Biechele Gloria,
Katzdobler Sabrina,
Bischof Gerard N,
Hammes Jochen,
Jessen Frank,
Saur Dorothee,
Schroeter Matthias L.,
Rumpf JostJulian,
Rullmann Michael,
Schildan Andreas,
Patt Marianne,
Neumaier Bernd,
Stephens Andrew W,
Rauchmann BorisStephan,
Perneczky Robert,
Levin Johannes,
Classen Joseph,
Höglinger Günter,
Bartenstein Peter,
Boening Guido,
Ziegler Sibylle,
Villemagne Victor L L,
Drzezga Alexander,
Seibyl John P,
Sabri Osama,
Brendel Matthias
Publication year - 2021
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.052563
Subject(s) - progressive supranuclear palsy , nuclear medicine , positron emission tomography , standardized uptake value , receiver operating characteristic , medicine , pathology , atrophy
Background Dynamic 60‐minute positron‐emission‐tomography (PET) imaging with the novel tau radiotracer [ 18 F]PI‐2620 facilitated accurate discrimination between patients with progressive supranuclear palsy (PSP) and healthy controls (HCs). We now aimed to investigate if shorter acquisition and static time windows of [ 18 F]PI‐2620 tau‐PET can be used for imaging of patients with PSP. Method We evaluated 37 patients at five different centers with probable or possible PSP Richardson syndrome (PSP‐RS) together with ten HCs. [ 18 F]PI‐2620 PET was performed by a dynamic 60 minute scan. Distribution volume ratios (DVRs, multilinear reference tissue model 2, cerebellar reference) were calculated using full and truncated scan durations (0‐60, 0‐50, 0‐40, 0‐30, and 0‐20 minutes p.i.). Standardized uptake value ratios (SUVrs, cerebellar reference) were obtained from static imaging windows with 20 minutes duration (20‐40, 30‐50, and 40‐60 minutes p.i.). All DVR and SUVr data were compared with regard to their potential to discriminate patients with PSP‐RS from HCs in predefined subcortical and cortical target regions (effect size, receiver operating area under the curve (AUC), multi‐region classifier). Finally, we tested if shorter [ 18 F]PI‐2620 PET imaging can also be applied to patients with Alzheimer’s disease (n=11). Result The effect size of 0‐50 and 0‐40 DVR was equivalent to 0‐60 DVR (averaged Cohen’s d: 1.22 and 1.16 vs. 1.26), whereas the performance dropped for 0‐30 or 0‐20 DVR. The 20‐40 SUVr indicated the best performance of all short static acquisition windows (averaged Cohen’s d: 0.99). The globus pallidus internus discriminated patients with PSP and healthy controls at a similarly high level for 0‐60 DVR (AUC: 0.96), 0‐40 DVR (AUC: 0.96), and 20‐40 SUVr (AUC: 0.94). The multi‐region classifier sensitivity of these time windows was consistently 86%. 0‐40 DVR showed similar performance in Alzheimer’s disease when compared to 0‐60 DVR. Conclusion Short dynamic acquisition and static imaging windows can be used for [ 18 F]PI‐2620 PET imaging of PSP. 0‐40 minute dynamic scanning offers the best balance between accuracy and economic scanning and is may also be suitable for [ 18 F]PI‐2620 PET imaging of Alzheimer’s disease.