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The cerebrospinal fluid interleukin 8 (IL‐8) concentration in Alzheimer’s disease (AD)
Author(s) -
Doroszkiewicz Julia,
KulczynskaPrzybik Agnieszka,
Dulewicz Maciej,
Borawska Renata,
Krawiec Anita,
Slowik Agnieszka,
Mroczko Barbara
Publication year - 2021
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.051317
Subject(s) - cerebrospinal fluid , neuroinflammation , dementia , microglia , alzheimer's disease , medicine , pathology , disease , tau protein , immunology , inflammation
Background Alzheimer disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. The hallmarks underlying AD pathology are amyloid‐β peptides, phosphorylated tau proteins and neuroinflammation. In vitro studies on cultured human microglia display a significant role of Interleukin 8 in neuroinflammation. Furthermore, CXCR2, IL‐8 receptor, was found in dystrophic neurites which suggests connection to neuroinflammation in AD. Literature data indicates that gene polymorphism in IL‐8 may affect the predisposition of Alzheimer's disease. It has been observed that IL‐8 may increase Tau phosphorylation and subsequent NFTs formation. Thus, the aim of our research was to measure the concentration of IL‐8 in cerebrospinal fluid of AD patients and non‐demented controls. Moreover, we compare them to the concentrations of classical AD biomarkers, such as Aβ‐42, Aβ‐42/Aβ‐40, Tau and pTau181. Method The concentrations of IL‐8 and classical AD biomarkers, such as Aβ‐42, Aβ‐42/Aβ‐40, Tau and pTau181 were measured in cerebrospinal fluid (CSF) of 15 AD patients and 16 non‐demented controls using immunoenzyme assays. Result IL‐8 concentrations were significantly higher in AD patients in comparison to non‐demented controls. Moreover, increased CSF levels of IL‐8 correlated with Aβ‐42/Aβ‐40 ratio, MMSE, Tau and pTau181 in the whole study group. Conclusion Findings of our research suggest a potential role of IL‐8 in pathology of AD. However, follow‐up studies on larger study group are needed. Acknowledgement: The study was conducted with the use of equipment purchased by Medical University of Białystok as part of the RPOWP 2007‐2013 funding, Priority I, Axis 1.1, contract No. UDA‐RPPD.01.01.00‐20‐001/15‐00 dated 26.06.2015.