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Interaction between amyloid and neuroinflammation on apathy along the Alzheimer’s disease spectrum
Author(s) -
Stevenson Alyssa,
Tissot Cécile,
Kang Min Su,
Benedet Andréa Lessa,
Rahmouni Nesrine,
Therriault Joseph,
Pascoal Tharick A.,
Chamoun Mira,
Lussier Firoza Z.,
Savard Mélissa,
Mathotaarachchi Sulantha,
Thomas Emilie,
Gauthier Serge,
RosaNeto Pedro
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.046638
Subject(s) - apathy , neuroinflammation , psychology , alzheimer's disease , neuroscience , disease , medicine , cognition
Background The Apathy Inventory is a rating scale given to informants in order to assess levels of apathy globally. This neuropsychiatric symptom is the most common noncognitive symptom in Alzheimer’s disease (AD), and it causes a great burden on diseased individuals and their caregivers. Even though it has been closely related to cerebrospinal fluid levels of neuroinflammation and amyloid, the interactive effect of pathologies is still unclear. Here we test the interaction between amyloid and neuroinflammation in the brain with apathy, along the AD spectrum. Method We assessed 59 individuals (38 cognitively unimpaired, 15 mild‐cognitive impairment, 6 AD) with [ 11 C]PBR28‐neuroinflammation positron‐emission tomography (PET) and [ 18 F]AZD4694‐amyloid PET. [ 11 C]PBR28 and [ 18 F]AZD4694 uptake value ratios (SUVRs) used the cerebellum grey matter as the reference region and were calculated 0‐90 min post‐injection and 40‐70 min post‐injection respectively. A voxel‐based regression model evaluated the relationship between the interaction of [ 18 F]AZD4694 and [ 11 C]PBR28 with Apathy scores. The model’s covariates were age, gender, education and diagnoses of the participants. Result We found a strong positive correlation between the interaction of [ 18 F]AZD4694 and [ 11 C]PBR28 with apathy. The most impacted regions were the medialfrontal cortex, in the superior portion and prefrontal cortex, as well as the anterior nucleus of the thalamus. Conclusion These preliminary results corroborate the link between amyloid and neuroinflammation, that potentiating the neuropsychiatric symptom apathy. The regions impacted are involved in proper behavior, such as the mediofrontal cortex. This study supports previous findings showing that amyloid and neuroinflammation are related to apathy.