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Levels of amyloid β in cerebrospinal fluid predicts cognition five years later: A population‐based study of 70‐year‐olds
Author(s) -
Skoog Johan,
Bodin Timothy Hadarsson,
Zetterberg Henrik,
Kern Jurgen,
Zettergren Anna,
Blennow Kaj,
Kern Silke,
Thorvaldsson Valgeir,
Skoog Ingmar
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.045969
Subject(s) - cerebrospinal fluid , medicine , population , verbal fluency test , dementia , cognition , verbal learning , cohort , psychology , neuropsychology , disease , psychiatry , environmental health
Background Few studies have investigated the relationship between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) and later cognitive function in the general population. The aim of this study was to study the association between Aβ42/40‐ratio, total‐tau (t‐tau) and phosfo‐tau (p‐tau) at age 70 and cognition at age 75 in a population‐based sample without dementia at baseline. Method The sample was derived from the population‐based Gothenburg H70 Birth Cohort Studies. A representative sample of 70‐year‐olds (N=1203, response rate=72%) were examined between 2014‐2016. A subsample of 316 individuals (26%) consented to a lumbar puncture and were free from dementia at age 70. Data have so far been collected on 72 individuals with CSF‐measures at age 70 and cognitive data at the follow‐up at age 75. CSF measures included Aβ42/Aβ40‐ratio, T‐tau and P‐tau, while cognitive tests comprised the Ray Auditory Verbal Learning Test (RAVLT), Semantic Fluency (animals) and Trail Making Test (TMT) A and B. Result At age 70, the prevalence of amyloid pathology was 22.8%, total tau pathology 33.2%, and phosphorylated tau pathology 6.9% in cognitively unimpaired individuals. Lower Aβ42/Aβ40‐ratio at age 70 was associated with lower verbal learning score (p<0.01), lower delayed recall (<0.0001) and lower verbal fluency score (p<0.05) at age 75. Aβ42/Aβ40‐ratio was not significantly associated with TMT, and T‐tau and P‐tau was not significantly related to any of the cognitive measures. Conclusion Our findings indicate that amyloid pathology precedes decline in cognition with at least five years while T‐tau and p‐tau does not.