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Sensitivity and specificity of EEG biomarkers of AD at the preclinical stage
Author(s) -
Noce Giuseppe,
Babiloni Claudio,
Lopez Susanna,
Percio Claudio Del,
Pascarelli Maria Teresa,
Lizio Roberta,
Teipel Stefan J.,
GonzálezEscamilla Gabriel,
Bakardjian Hovagim,
George Nathalie,
Cavedo Enrica,
Lista Simone,
Chiesa Patrizia Andrea,
Vergallo Andrea,
Lemercier Pablo,
Spinelli Giuseppe,
Grothe Michel,
Potier MarieClaude,
Stocchi Fabrizio,
Ferri Raffaele,
Habert MarieOdile,
Fraga Francisco J.,
Dubois Bruno,
Hampel Harald
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.045832
Subject(s) - neuropathology , psychology , dementia , neuroscience , neuroprotection , audiology , electroencephalography , neurodegeneration , positron emission tomography , clinical dementia rating , medicine , cognition , disease , cognitive impairment
Background Cognitive reserve (CR) is present in Alzheimer’s disease (AD) seniors with high education attainment making them clinically resilient to extended brain neuropathology and neurodegeneration. Here we tested whether subjective memory complaint (SMC) seniors with AD neuropathology and high education attainment may present abnormal eyes‐closed resting state posterior electroencephalographic (rsEEG) rhythms around individual alpha frequency peak (IAFp), typically altered in AD patients with mild cognitive impairment and dementia. Method We selected all individual baseline data of the prospective INSIGHT‐preAD cohort (Paris) including mini mental state examination score ≥ 28, artifact‐free markers of 18F‐florbetapir positron emission tomography (amyPET), structural magnetic resonance imaging, and rsEEG rhythms (e.g., 172 SMC seniors). Delta, theta, alpha1, alpha2, and alpha3 bands were determined on individual basis based on IAFp, while beta1 (14‐20 Hz), beta2 (20‐30 Hz), and gamma (30‐40 Hz) were standard fixed bands. Result The SMC participants negative to amyPET AD markers (SMCneg) with high (over low‐moderate) education level showed higher posterior alpha 2 power density (possibly “neuroprotective”). Furthermore, amyPET‐positive SMC (SMCpos) participants with high (over low‐moderate) education level showed higher temporal alpha 3 power density (possibly “neuroprotective”) and lower posterior alpha 2 power density (possibly “compensatory”; Figure 1). This effect may reflect CR as no differences in brain gray‐white matter and cognitive functions were observed between these SMCpos/SMCneg sub‐groups. Conclusion Preclinical Alzheimer’s neuropathology may interact with education attainment and neurophysiological mechanisms generating cortical alpha rhythms around IAFp (i.e., alpha 2 and 3) in quiet wakefulness.