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Different abnormalities of electroencephalographic (EEG) markers in quiet wakefulness are related to motor visual hallucinations in patients with Parkinson’s and Lewy body diseases
Author(s) -
Lopez Susanna,
Percio Claudio Del,
Pascarelli Maria Teresa,
Lizio Roberta,
Noce Giuseppe,
Ferri Raffaele,
Soricelli Andrea,
Nobili Flavio Mariano,
Arnaldi Dario,
Famà Francesco,
Bonanni Laura,
Franciotti Raffaella,
Onofrj Marco,
Fuhr Peter,
Gschwandtner Ute,
Ransmayr Gerhard,
Aarsland Dag,
Parnetti Lucilla,
Farotti Lucia,
Marizzoni Moira,
D'Antonio Fabrizia,
de Lena Carlo,
Güntekin Bahar,
Hanoğlu Lutfu,
Yener Görsev,
EmekSavas Derya Durusu,
Triggiani Antonio Ivano,
Taylor JohnPaul,
McKeith Ian,
Stocchi Fabrizio,
Vacca Laura,
Hampel Harald,
Frisoni Giovanni B,
Pandis Maria Francesca,
Babiloni Claudio
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.045811
Subject(s) - dementia with lewy bodies , dementia , parkinson's disease , pathological , lewy body , electroencephalography , audiology , neuroscience , psychology , disease , medicine , population , cognition , physical medicine and rehabilitation , psychiatry , environmental health
Background Parkinson’s disease (PD) is the second‐most common neurodegenerative disorder that affects 2–3% of the population ≥ 65 years of age and may belong to cognitive deficits and dementia in 50% of cases. Disease with Lewy Bodies (DLB) is emerging as another important cause of dementia in pathological aging. PD and DLB are both due to intra‐neuronal Lewy bodies and are characterized not only by motor dysfunctions but also by cognitive and/or psychiatric symptoms. An open issue is the extent to which these diseases are distinct entities. In this respect, here we compared cortical sources of resting state eyes‐closed electroencephalographic (rsEEG) rhythms in PD and DLB patients having visual hallucinations. Method Clinical and rsEEG rhythms in demographic matched PD (N = 93), DLB (N = 46), Alzheimer’s disease dementia (AD, N= 70) and healthy elderly (Nold, N = 60) subjects were available from an international archive. Pathological groups were matched for cognitive status. Individual alpha frequency peak was used to determine the delta, theta, alpha1, alpha2, and alpha3 frequency band ranges. Fixed beta1, beta2, and gamma bands were considered. The eLORETA freeware estimated rsEEG cortical sources. Result As a confirmation of previous studies, compared to the Nold subjects, the AD, LBD, and PD patients showed higher widespread delta source activities and lower posterior alpha source activities. Specifically, posterior alpha source activities were more abnormal in the AD than the LBD and PD groups, while widespread delta source activities were more abnormal in the PD and DLB than the AD group. As novel results, in relation to the LBD and PD patients without visual hallucinations and the control groups (Nold, AD), those with visual hallucinations were characterized by higher parietal delta source activities (LBD, Figure 1) and parieto‐occipital alpha sources activities (PD, Figure 2). Conclusion These novel results suggest that in LBD and PD patients resting in the quiet wakefulness, abnormalities in cortical neural synchronization at delta and alpha frequencies in parietal cortex are differently related to visual hallucinations despite the essence of alpha‐synucleinopathy.