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Difference of quantitative EEG between Alzheimer’s disease (AD) dementia and non‐dementia AD
Author(s) -
Kang Seung Wan,
Choi Seong Hye,
Jeong Jee Hyang,
Jang JaeWon,
Park KyungWon,
Kim EunJoo,
Kim Hee Jin,
Hong Jin Yong,
Yoon Soo Jin,
Yoon Bora,
Kang Dong Won
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.044300
Subject(s) - dementia , neurocognitive , audiology , psychology , electroencephalography , alzheimer's disease , clinical dementia rating , resting state fmri , cognition , neuroscience , disease , medicine
Abstract Background Alzheimer’s disease (AD) is the most common cause of dementia. However, accumulation of beta amyloid plague in the brain which is main pathology of AD could show the various spectrum of cognitive functional stage from preclinical level to overt dementia. It is important to understand functional differences between dementia and non‐dementia of AD to predict progression forward to dementia at prodromal or preclinical stage of AD. Method Nineteen channels of resting state EEGs were measured from 45 Alzheimer’s disease subjects who were all confirmed by brain amyloid‐beta PET. Neurocognitive test, activity of daily living (ADL) and MRI were conducted for clinical diagnosis. EEG power spectrum analysis and band‐power ratio, cortical source current density estimated by standardized low resolution brain electromagnetic tomography(sLORETA), functional connectivity between 68 region of interest (ROI) based on imaginary coherence(iCoh) and complex brain networks were analyzed. Result 20 AD subjects (age: 76.8±7.54) were assessed as dementia, and the other 25 (age: 72.1±6.89) as mild cognitive impairment (MCI) or subjective cognitive decline (SCD) depending on delayed recall memory score. Average CDR was 0.23 in non‐dementia and 1.15 in dementia group. There was no significant difference at delta, but theta power of AD dementia group was significantly increased at all 19 scalp channels. Mid frontal channel (Fz) showed the most distinctive enhancement of theta power. In other hands, beta1 (12∼15Hz) was significantly increased at both temporoparietal area in non‐dementia AD group. These patterns about theta increase and beta 1 decrease in AD dementia group were observed very similarly in cortical source current density. iCoh among ROIs of default mode network (DMN) was significantly decreased at alpha2 band (10∼12Hz). At bilateral frontal pole, rostral middle frontal, anterior cingulate, parahippocampus and precuneus, the degree centrality and characteristic path length significant increased at theta band. In contrast, theta of cluster coefficient and closeness centrality significantly decreased. Conclusion AD dementia showed increase of theta and decrease of bet1 both at scalp and cortical level comparing to non‐dementia AD subjects. Both global and local network efficiencies via theta wave were significantly deteriorated in AD dementia. QEEG could well discriminate the differences between dementia and non‐dementia in ADs.