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H. pylori infection is associated with cortical thinning in cognitively normal individuals
Author(s) -
Park Jaehong,
Song Joohye,
Shin Hee Young,
Jang Hyemin,
Na Duk L,
Seo Sang Won,
Kim Tae Joon,
Kim Hee Jin
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.044295
Subject(s) - esophagogastroduodenoscopy , medicine , helicobacter pylori , endoscopy
Background Helicobacter pylori (H.pylori) is a well known bacteria for development of stomach cancer and chronic inflammation. However, H.pylori’s contribution to the neurodegeneration remains largely unknown. We aimed to evaluate the association between H.pylori infection and brain cortical thickness in cognitively normal individuals. Method We recruited 1,926 cognitively normal individuals (age≥ 45 years) who underwent brain 3‐dimensional volume MR images and esophagogastroduodenoscopy biopsy to determine H. pylori infection. The participants were recruited from Health Promotion Center in Samsung Medical Center from September 2008 to December 2014. After excluding participants with missing variables, 1,594 were selected in final analysis. We measured cortical thickness using the standard Montreal Neurological Institute image processing tool CIVET. Multiple linear regression analysis was done to evaluate the relationship between H.pylori infection and brain cortical thickness after controlling for age, intracranial volume, education, CRP, and the presence of metabolic syndrome. Result In male, H. pylori infection was associated with cortical thinning in the bilateral lateral temporal, lateral frontal, and right occipital areas. However, in female, H. pylori infection was not associated with cortical thickness. Conclusion Our findings suggest that H.pylori infection is associated with neurodegenerative changes in cognitive normal male, regardless of chronic inflammation or metabolic syndrome.