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Mild behavioral impairment checklist differentiates normal controls and MCI in a well‐characterized sample
Author(s) -
Sewell Margaret,
Neugroschl Judith,
Zhu Carolyn W.,
Krystal Hannah,
Thepmankorn Parisa,
Velasco Nelly,
Martin Jane,
Sano Mary
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.044271
Subject(s) - checklist , cognitive impairment , clinical psychology , dementia , demographics , psychology , clinical dementia rating , medicine , cognition , psychiatry , demography , disease , sociology , cognitive psychology
Abstract Background Neuropsychiatric symptoms (NPS) are common early signs of cognitive impairment and dementia. The Mild Behavioral Impairment (MBI) Checklist was created to capture these symptoms. Our objective was to use the MBI to measure NPS in non‐demented normal and MCI research participants and to identify associations among MBI and other established clinical and demographic measures. Methods ADRC participants with MCI (N=52) or NC (N=84) completed the MBI. The MBI’s 34 yes/no questions assess decreased motivation, emotional dysregulation, impulse dyscontrol, social inappropriateness, and abnormal perception/thought content. ‘Yes’ answers were ranked in severity on a Likert scale of 1 (Mild) to 3 (Significant). Responses were summarized to create global (range 0‐102, with lower scores representing fewer symptoms) and domain scores which were compared in MCI/NC groups. Correlations were run by diagnostic group for the MBI and the demographic and clinical variables. Multivariable regression models examined the relationship between MBI total and diagnosis after controlling for participant characteristics. Results The characteristics of our total sample were: (mean±SD) age=76.6±8.2, 64% female, 56.4% non‐Hispanic white, 26.3% Hispanic,17.3% non‐Hispanic black, and education 15.3±4.1 years. As regards demographics, there were no statistical differences between NC and MCI. In the MCI group, the MOCA (lower), GDS, NPIQ, FAQ (higher) were all significantly different from the NC group (all p<0.05). MBI total was significantly higher in the MCI group (mean MCI 11.7±15.9, NC 5.2±8.0 p<0.001). MBI domain scores were significantly higher as well (all p<0.01) except for impulse control (p=0.07). For both the MCI and NC groups, MBI‐total was significantly negatively correlated with education and positively with depression in the past 2 years as well as current GDS (all p<0.05). In multivariate regression analyses these significant associations remained. Conclusion Controlling for demographic factors and comorbidities, MBI scores are significantly different between normal controls and those with MCI.