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Association of brain amyloid accumulation and glucose hypometabolism with memory loss
Author(s) -
Wang Ying,
Huang Qi,
Ren Shuhua,
Huang Lin,
Jiang Donglang,
Li Junpeng,
Guan Yihui,
Guo Qihao,
Xie Fang
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.043715
Subject(s) - precuneus , cuneus , posterior cingulate , verbal learning , neuropsychology , superior frontal gyrus , verbal memory , boston naming test , lingual gyrus , psychology , neurodegeneration , cognitive decline , neurocognitive , entorhinal cortex , audiology , medicine , cognition , hippocampus , neuroscience , pathology , dementia , disease
Background Memory loss is the main syndrome of Alzheimer’s disease (AD). Extracellular accumulation of amyloid‐β (Aβ) neuritic plaques and neurodegeneration such as glucose hypometabolismwere the main pathology of AD. In this study, we try to figure out the association of Aβ accumulation and glucose hypometabolism with memory loss. Methods 91 normal cognition (NC) healthy volunteers, 37 subjective cognitive decline (SCD), 32 mild cognition impairment (MCI) and 34 AD patients were enrolled in this study from Chinese preclinical Alzheimer’s disease (C‐PAS), which is initiated by Shanghai Jiao Tong University Affiliated Sixth People’s Hospital and Huashan Hospital. 6 types of neuropsychological tests from 3 cognitive core, including Auditory verbal learning test (AVLT) 30‐minute delayed free recall and AVLT recognition for memory, MMSE, Moca B were performed. FDG and amyloid PET (18F‐Flortabetapir) were conducted in these participants. 18F‐FDG and 18F‐Flortabetapir PET images were coregistered to the individual structural MRI images and then spatially normalized into MNI space. The associations of FDG and Aβ with impairment of language were explored by performing multiple regression between the 18F‐FDG and neuropsychological scores, as well as 18F‐Flortabetapir PET images and neuropsychological scores with age, gender, educationalyears as covariates. The statistical level was set at p<0.05 with FDR correction and a minimum cluster extent Ke>20 voxels. Results No relationship was found between memory loss and amyloid accumulation. Glucose metabolism in precuneus, middle frontal cortex, cuneus, posterior cingulate gyrus has association with AVLT 30‐minute delayed free recall. Association was observed between glucose metabolism in inferior frontal cortex, insula and AVLT recognition. Conclusion Associations were observed between memory loss and glucose hypometabolism, but no association was found between amyloid and memory loss.