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Different effects of metabolic syndrome according to dementia type
Author(s) -
Kim Yeo Jin
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.042370
Subject(s) - metabolic syndrome , dementia , medicine , dyslipidemia , vascular dementia , cohort , diabetes mellitus , type 2 diabetes mellitus , disease , population , abdominal obesity , obesity , endocrinology , environmental health
Background Metabolic syndrome is a cluster of components that reflect overnutrition, which including hypertension, diabetes, dyslipidemia and obesity. Although metabolic syndrome is a risk factor of cardiovascular disease and type 2 diabetes mellitus, the association between metabolic syndrome and dementia has remained controversial. Using nationwide population cohort data, we investigated the association between metabolic syndrome and dementia in Gangwon province in South Korea. Method We analyzed data of Gangwon province for 127,666 individuals aged more than 60 years in the (Korean) National Health Insurance Service (NHIS) cohort who were enrolled between January 1, 2009 and December 31, 2009. Then we investigated the presence of dementia in 2017. We classified type of dementia as Alzheimer’s disease dementia (ADD) and vascular dementia (VD). Dementia including ADD and VD was defined according to criteria in the International Classification of Disease, Tenth Revision, Clinical Modification (ICD‐10‐CM) codes. Result Metabolic syndrome was associated with ADD, while it was not associated with VD. Previous stroke was associated with both ADD and VD. Rather than metabolic syndrome, VD was associated with smoking. All five components of metabolic syndrome associated with ADD, independently. However, among components of metabolic syndrome, only high glucose associated with VD. In ADD, it was most relevant when there were three of the five components of metabolic syndrome, while in VD, it was only relevant when there were all five components of metabolic syndrome. Conclusion Metabolic syndrome was associated with ADD, while was not associated with VD. VD was associated only with several risk factors that could affect the vascular state rather than metabolic syndrome. We suggested that the effect of metabolic syndrome on dementia would be different depending on the type of dementia.