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Biobank innovations for chronic cerebrovascular disease with Alzheimer's disease study (BICWALZS)
Author(s) -
Son Sang Joon,
Park Bumhee,
Roh Hyung Woong,
Kim Narae,
Jo Yong Hyuk,
Lee Eunyoung,
Lee Kyoungmin,
Lee Haelim,
Ha Jae Ho,
Lee Kang Soo,
Kim EunJoo,
Seo Sang Won,
Choi Seong H.,
Hong Chang Hyung
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.042259
Subject(s) - biobank , medicine , dementia , cohort , magnetic resonance imaging , neuropsychology , prospective cohort study , positron emission tomography , vascular dementia , disease , neuropsychological assessment , cohort study , neurocognitive , physical therapy , physical medicine and rehabilitation , cognition , psychiatry , radiology , bioinformatics , biology
Abstract Background Biobank Innovations for chronic Cerebrovascular disease With ALZheimer’s disease Study (BICWALZS) aimed to recruit 650 individuals, aged from 40 to 90 years, to investigate how chronic cerebrovascular contribute to the brain changes or brain pathologies related to the Alzheimer’s disease (AD) process. Method All participants received comprehensive clinical and neuropsychological evaluations, multi‐modal brain imaging, including magnetic resonance imaging (MRI), magnetic resonance angiography, Flutemetamol positron emission tomography (PET), blood and genetic marker analyses at baseline, and a subset of participants underwent actigraphy monitoring and fibroblast sampling. Participants are to be followed annually with brief clinical assessments, and some subjects with amyloid or subcortical ischemia are evaluated biannually with the full assessment, including neuropsychological, MRI and laboratory tests. Results In total, 543 individuals had volunteered for this study. Among them, 345 individuals with mild cognitive impairment (MCI), 44 individuals with subcortical vascular dementia(SVaD) and 154 individuals with AD dementia (ADD)–were enrolled at baseline. Conclusion The BICWALZS cohort is a prospective, longitudinal cohort study that recruited participants with a wide age range and a wide distribution of cognitive status (MCI, SVaD and ADD) and it has several strengths in its design and methodologies. Details of the recruitment, study methodology, and baseline sample characteristics are described in this paper.