Premium
Association of Apolipoprotein E genetic variation in Alzheimer's disease in a Korean population
Author(s) -
Van Vo Giau,
Bagyinszky Eva,
An Seong Soo,
Kim SangYun
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.041859
Subject(s) - apolipoprotein e , allele , genotype , disease , alzheimer's disease , medicine , polymorphism (computer science) , population , allele frequency , korean population , genetics , oncology , biology , gene , environmental health
Background Alzheimer’s disease (AD) is one of the most devastating neurodegenerative diseases. The relationship between Apolipoprotein E (ApoE) genotype and the risk of AD is well described in Caucasians, but less established in other ethnicities. Method To examine the association between ApoE polymorphism and the onset of AD in Korean population, we enrolled and examined a total of 1000 Korean patients using polymerase chain reaction. The patients were assessed using the criteria of the National Institute of Neurological and Communicative Disorders and Stroke Alzheimer’ Disease and Related Disorders Association. Result The frequency of alleles ε2, ε3 and ε4 were 0.076, 0.784 and 0.292, respectively, in Koreans with AD. Furthermore, we compared our allele frequency data with that from other studies of Asian populations using cluster analysis. APOE genotype was closely related to AD in the Japanese population, which was entirely consistent with results previously reported from Korea. Conclusion This study confirmed that the subject with at least one ApoE ε4 allele has higher risk suffering from AD than controls in Korean population.