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The quantitative analysis of tau deposition using [F18] PI‐2620 dynamic PET acquisition in cognitively normal subjects, mild cognitive impairment and Alzheimer’s disease patients
Author(s) -
Jantarato Attapon,
Vachatimat Sira,
Assanasen Jintana,
Kunawudhi Anchisa,
Promteangtrong Chetsadaporn,
Chotipanich Chanisa
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.041825
Subject(s) - cognitive impairment , fusiform gyrus , medicine , temporal lobe , standardized uptake value , nuclear medicine , psychology , alzheimer's disease , cognition , cardiology , disease , positron emission tomography , psychiatry , epilepsy
Background F‐18 PI 2620 has been reported as an effective tau binding radiotracer. However, there are few reports focusing on the quantitative analysis. Hence, this study aims on the quantitative analysis of PI 2620 in individuals with normal cognition, MCI and AD. Method Twenty‐six cognitively normal (CN; 8 men, 18 women; aged 56–71 years; mean age ± SD: 63.81 ± 4.6 years), 7 Alzheimer’s disease (AD; 3 men, 4 women; aged 59–74 years; mean age ± SD 64.57 ± 6.09 years), and 36 mild cognitive impairment (MCI; 11 men, 25 women; aged 56–85 years; mean age ± SD 66.61 ± 5.92 years) individuals were enrolled. A dynamic F‐18 PI 2620 PET was performed at 30‐75 minutes post‐injection. Co‐registration was employed between the PET and T1‐weighted MRI. The standardized uptake value ratio (SUVR) was used for quantitative analysis. P‐mod software with the Automated Anatomical Labeling (AAL)‐merged atlas was applied to create volumes of interest. Pair t‐test in STATA was applied for statistical analysis. Result In AD group, occipital lobe had the most significantly higher mean SUVR (1.46±0.57) compared to both CN (1.08±0.09, p <0.01) and MCI group (1.06±0.08, p <0.001). Comparing to CN, AD brain also showed significantly higher mean SUVR ( p <0.05) in fusiform gyrus (1.06±0.09 vs. 1.49±0.86), inferior temporal (1.07±0.07 vs. 1.46±0.08), parietal lobe (1.01±0.13 vs. 1.27±1.45), lingual gyrus(1.08±0.11 vs. 1.29±0.41) and precuneus (1.02±0.12 vs. 1.27±0.45).Likewise the AD group demonstrated higher mean SUVR than MCI in precuneus (1.00+0.07), lingual (1.07±0.12), inferior temporal (1.06±0.10), fusiform (1.08±0.11), supramarginal (0.97±0.07), orbitofrontal (0.97±0.07) and superior temporal (0.95±0.07) regions. The remaining observed regions including striatum, basal ganglia, thalamus, white matter, showed low SUVR across three groups without statistical significant. Conclusion The significantly higher mean SUVR of F‐18 PI 2620 was observed in the AD group at significant brain area for diagnosis Alzheimer’s disease demonstrated tau protein deposit in‐concordance with the Braak Staging III‐V, providing useful information to differentiate AD from CN and MCI. Moreover, low SUVR in deep striatum and thalamus could be useful for the exclusion of primary tauopathies such as progressive supranuclear palsy.