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Study on the correlation of depression, cognitive function and living ability in Chongqing, China
Author(s) -
Yang Wenkai,
Lü Yang
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.041619
Subject(s) - geriatric depression scale , depression (economics) , medicine , cognition , activities of daily living , geriatrics , mood , cognitive impairment , worry , gerontology , psychiatry , psychology , anxiety , depressive symptoms , economics , macroeconomics
Background To examine the incidence of depression in elderly people over 60 in Chongqing and patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD) in the Memory Clinic of Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University. Method A total of 188 patients with MCI and 275 patients with AD who attended the Memory Clinic of Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, from January 2010 to December 2018. 317 community subjects without cognitive impairment were used as control in this study. The neuropsychological examination was conducted for all patients, and the demographics were recorded. In addition, depression and impairment of daily living were evaluated by the Geriatric Depression Scale (GDS‐30) and Activity of Daily Living (ADL) respectively. Result Depression was identified in 8.83% of subjects without cognitive impairment, 25.53% of patients with MCI, 25.09% of patients with AD. Compared with those without cognitive impairment, patients with cognitive impairment showed different symptoms in dysphoric mood, lack of vitality, worry, self‐evaluation of cognitive function, hopelessness and agitation (p<0.05). Furthermore, lack of vitality and self‐evaluation of cognitive function still remained statistically significant after adjustment for age, sex, and education level by logistic regression analysis [OR(95%CI(=1.312(1.164‐1.478) and 1.482(1.282‐1.714(,p<0.05].In addition, there was a close correlation between depression severity and cognitive function and living ability, that is, the low depression level (the low GDS score) indicates a good cognitive function (a high MMSE score) and living ability (a high ADL score). Conclusion Depressive symptoms show slight difference in patients with cognitive impairment or not. The health promotion for dementia‐related diseases in Chongqing still needs to be further promoted.