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Depression and anxiety disorder along life in familial Alzheimer’s disease in the API ADAD Colombia trial
Author(s) -
Ramos Claudia,
RiosRomenets Silvia,
GiraldoChica Margarita,
AcostaBaetalia,
Tobon Carlos,
Lopez Hugo,
AguirreAcevedo Daniel C.,
Langbaum Jessica B.,
Reiman Eric M.,
Tariot Pierre N.,
Lopera Francisco
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.041314
Subject(s) - psen1 , dementia , anxiety , disease , medicine , depression (economics) , clinical dementia rating , psychiatry , population , alzheimer's disease , asymptomatic , asymptomatic carrier , presenilin , macroeconomics , environmental health , economics
Background Some late‐onset Alzheimer’s disease studies suggest that affective disorders begin before cognitive impairment and promote decline. Nevertheless, it has been observed that in Autosomal Dominant Alzheimer’s Disease (ADAD), asymptomatic mutation carriers have a lower risk of disorders such as depression compared to non‐carriers. The relationship between affective disorders and Alzheimer’s disease would be clearer if there were more studies in preclinical Alzheimer’s disease. Currently, the biggest population of familial Alzheimer’s disease, caused by the PSEN1 E280A mutation, is located in Colombia. The Alzheimer’s Prevention Initiative (API) ADAD Colombia trial is being conducted with PSEN1 E280A carriers and non‐carriers, cognitively unimpaired at baseline. During screening, investigators asked about antecedents of mental health disorders. We examined whether asymptomatic mutation carriers reported a different rate of affective disorders compared to non‐carriers. Objective To compare the prevalence of affective disorders between PSEN1 E280A mutation carriers and non‐carriers at the time of API ADAD trial screening. Method We performed a retrospective analysis to understand the history of affective disorders (reported by participants), after screening 315 mutation carriers and non‐carriers aged 30 ‐60 years. The comparison between carriers and non‐carriers was made by a generalized linear regression model. Results were adjusted by age, gender, educational level and the Clinical Dementia Rating (CDR) scale. Odds ratios (OR) were used as measure of association, with a 95% confidence interval (95%CI). Result 315 candidates underwent screening: 210 carriers and 105 non‐carriers. Of people with antecedent of affective disorders, 65 (30.9%) were mutation carriers and 32 (30.5%) were non‐carriers. Comparing carriers with non‐carriers, the OR for depression was 1.010 (95%CI 0.492 – 2.113) and for anxiety was 1.325 (95%CI 0.485 – 3.938). Results were similar after excluding 15 participants with CDR of 0.5. Conclusion Although there were no differences between groups, the prevalence of affective disorders through life was high in carriers and non‐carriers, compared to the adult Colombian population (30.8% vs 6.7%). Possible reasons include: 1) Concern about having a family with an elevated risk of AD; 2) observing the progressive decline of close relatives; 3) living with or caring for persons with dementia.