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Cortical thickness of parahippocampal gyrus discriminates mild cognitive impairment (MCI) groups with different profiles of CSF biomarkers
Author(s) -
Fernández Miguel Ángel Rivas,
AldreyVázquez Jose M.,
LojoSeoane Cristina,
Lindín Mónica,
PíasPeleteiro Juan M.,
Vieites Aieto,
Zurrón Montserrat,
DomínguezVivero Clara,
CamposMagdaleno Maria,
Pereiro Arturo X.,
Díaz Fernando
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.040944
Subject(s) - parahippocampal gyrus , entorhinal cortex , dementia , alzheimer's disease , medicine , psychology , gyrus , superior frontal gyrus , cortex (anatomy) , pathology , neuroscience , hippocampus , cognition , disease , temporal lobe , epilepsy
Background Mild cognitive impairment (MCI), clinically considered an intermediate state between the cognitive changes of normal aging and early dementia (Petersen, 2016), progress frequently to Alzheimer´s clinical syndrome. Alzheimer Disease (AD) biomarkers are used to evaluate the etiology and progression of MCI. In this study, we evaluated whether MCI participants with different profiles of CSF biomarkers (proposed by the National Institute on Aging and Alzheimer's Association ‐Jack et al., 2018‐) show differences in cortical thickness measures of the parahippocampal gyrus subregions. Method Seventy‐eight patients from the Compostela Aging Study diagnosed as MCI according to the Petersen criteria (Petersen, 2004; Albert et al., 2011) underwent neuropsychological assessment, CSF (β‐amyloid, p‐tau and t‐tau), and MRI cortical thickness measures of the parahippocampal gyrus. Subcortical segmentation of T1‐weighted MR images was conducted with FreeSurfer (6.0 version) using the “recon‐all” pipeline to obtain the mean thickness measures of the parahippocampal and the entorhinal cortex of each participant. Participants were classified into four groups according to CSF biomarkers: Group 1: Normal AD with MCI; Group 2: Alzheimer’s pathologic change with MCI; Group 3: Alzheimer’s disease with MCI (Prodromal AD); and Group 4: non‐Alzheimer’s pathologic change with MCI. General lineal models were performed to evaluate Group differences in the cortical thickness measures. Results The MCI Group 1 showed significantly higher cortical thickness than: a) Group 3 in right and left parahippocampal cortex, and b) Group 2 in right entorhinal cortex (Table 1 and Figure 1). No other significant differences were obtained. Conclusions The MCI CSF profile groups 3 (“prodromal AD”) and 2 (“Alzheimer´s pathologic change”) showed significant parahippocampal gyrus atrophy compared with MCI group 1 (“normal AD”). These results support MCI profiles proposed by Jack et al. (2018). Moreover, considering the degeneration of medial temporal lobe in AD, the aforementioned changes might have an AD diagnostic and prognostic value for both MCI groups.