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Diagnosis of Alzheimer's disease with eye examination
Author(s) -
Lü Yang,
Qin Zhang Jin
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.038929
Subject(s) - quadrant (abdomen) , medicine , retinal , ophthalmology , receiver operating characteristic , significant difference , optical coherence tomography , audiology , area under the curve , surgery
Background To evaluate the retinal changes in patients with Alzheimer's disease(AD) by combining pattern visual evoked potential(PVEP) and optical coherence tomography(OCT) and to study their diagnostic effects on AD. Method 31 patients with AD and 37 normal elderly were involved in the study. The patients with AD were diagnosed in the First Affiliated Hospital of Chongqing Medical University between August 1, 2018 and November 30,2019, and the normal elderly were recruited from the local community. PVEP and OCT were performed on all subjects, and then the latency and amplitude of P100 wave in PVEP, the pRNFL thickness of each quadrant in OCT were recorded, and the difference between AD and HC(Health Control) was analyzed to study its diagnostic value for AD. Result Compared with the HC group, the amplitude of P100 wave in the AD group was significantly lower (p<0.05), and there was no difference in latency of P100 wave (p>0.05);The thickness of pRNFL was significantly thinner in the nasal, superonasal, superotemporal and Inferotemporal quadrant(p<0.05), and there was no difference in the temporal and Inferonasal quadrant(p>0.05). And by ROC curve analysis, it was found that the AUC of a single parameter of either retinal function or structure was lower than the AUC of multiple parameter combinations. Conclusion The amplitude of P100 wave combined with pRNFL thickness of superonasal and superotemporal has a high diagnostic efficiency for identifying patients with or without AD. This suggests that the combination of PVEP and OCT provides a good clinical biomarker for the diagnosis of AD.