Premium
Relationship between carotid atherosclerosis and plasma Aβ levels in patients with high risk of stroke
Author(s) -
Wang Anqi,
Gao Ling,
Wei Shan,
Dang Liangjun,
Shang Suhang,
Chen Chen,
Wang Jin,
Huo Kang,
Deng Meiying,
Wang Jingyi,
Qu Qiumin
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.038711
Subject(s) - medicine , univariate analysis , stroke (engine) , pathogenesis , population , gastroenterology , carotid arteries , cardiology , multivariate analysis , mechanical engineering , environmental health , engineering
Background Growing evidence indicated that vascular factors contributed to the pathogenesis of Alzheimer’s disease (AD), but the relationship of atherosclerosis and AD is unclear. As Amyloid‐β (Aβ) deposition in the brain is a main pathophysiology of AD and plasma Aβ is closely related to Aβ deposition in the brain. In present study, we investigated the relationship between carotid atherosclerosis and plasma Aβ levels. Method Patients with high risk of stroke were from community stroke screening in Qubao Village, Xi'an. Carotid ultrasound was used to detect carotid atherosclerosis. Venous blood was collected on an empty stomach in the morning. Plasma Aβ 1‐40 and Aβ 1‐42 levels were measured by ELISA. Univariate and multivariate analysis were used to investigated carotid atherosclerosis and plasma Aβ 1‐40 and Aβ 1‐42 levels. Result Among 222 participants underwent carotid ultrasound, 149 had carotid atherosclerosis (49.01%). Univariate analysis showed that plasma Aβ 1‐40 level and Aβ 1‐42 level had no significant differences between carotid atherosclerosis group and non‐carotid atherosclerosis group (53.15 ± 8.77 vs. 50.96 ± 8.79 pg/ml, P =0.083; 41.07 ± 6.51 vs. 39.95 ± 5.93 pg/ml, P =0.217). Multivariate linear regression analysis showed that plasma Aβ 1‐40 (b=1.832, p = 0.213), plasma Aβ 1‐42 (b=1.605, P =0.131) and plasma Aβ 1‐40 /Aβ 1‐42 ratio (b=‐0.012, P = 0.829) had no significant difference between two groups in the total population. However, in the non‐hypertensive population, plasma Aβ 1‐40 and Aβ 1‐42 were significantly higher in the carotid atherosclerosis group than those in the non‐carotid atherosclerosis group (b=6.774, 95% CI: 2.691‐10.858 pg/ml, P =0.001; b=3.408, 95% CI: 0.309‐6.508 pg/ml, P =0.032). Conclusion Among patients with high risk of stroke, carotid atherosclerosis was associated with higher plasma Aβ levels in non‐hypertension group. These indicated that atherosclerosis may be related to AD, and the relationships may be confounded by hypertension.