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Implication of healthy lifestyles and the taking of Fortasyn Connect © in the cognitive impairment evolution
Author(s) -
ZeaSevilla María Ascensión,
Palomo María Sagrario Manzano
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.038516
Subject(s) - medicine , disease , overweight , cognition , mediterranean diet , diabetes mellitus , gerontology , dementia , physical therapy , psychology , obesity , psychiatry , endocrinology
Background There is increasing evidence that beyond modifiable risk factors there are modifiable factors associated with Alzheimer's disease, including those related to cardiovascular risk ‐ high blood pressure, hypercholesterolemia, diabetes, smoking and overweight. And with a diet lifestyle, physical exercise and cognitive and social activity. Based on this premise, we analyze on a series of patients treated with Fortasyn connect (Souvenaid ® ) their “healthy life” habits. Method On 39 patients with mild cognitive impairment or mild Alzheimer's disease in treatment with Souvenaid ® , life habits questionnaires were completed in daily and leisure activities, in social and food participation. Result We studied 39 subjects around the age of 81.1 years (± 4.5), in treatment with Souvenaid ® (53.8% associated with IAch and 10.3% with memantine). Compliance with Souvenaid ® treatment was 79.5% (due to intolerance dropped 7.7%). The mean treatment follow‐up of patients who finished the study was 12.9 months (± 8.0). The adherence to the Mediterranean diet was moderate. 37.8% of the subjects maintained or improved the MMSE score at the time of follow‐up. The loss of the monthly MMSE score tended to be greater in the elderly (p = 0.082) and was significantly lower in those who regularly drove (p = 0.009), read (p = 0.036) or engaged in light physical activity (p = 0.018). In the multivariate study, driving and light physical activity was associated with a lower monthly loss of MMSE. Conclusion The study of healthy lifestyles could help elucidate the best combination of pharmacological and non‐pharmacological treatments, in order to develop a "precision medicine" approach and an individual and multimodal strategies, in order to prevent, diagnose and develop therapies more precise and effective against AD.