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The relationship between sleep disturbance and cognitive impairment: A population‐based cross‐sectional study
Author(s) -
Gao Fan,
Gao Ling,
Wei Shan,
Dang Liangjun,
Shang Suhang,
Chen Chen,
Wang Jin,
Huo Kang,
Deng Meiying,
Wang Jingyi,
Qu Qiumin
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.038278
Subject(s) - pittsburgh sleep quality index , sleep disorder , cross sectional study , primary insomnia , cognition , population , univariate analysis , sleep (system call) , logistic regression , medicine , cognitive impairment , psychology , montreal cognitive assessment , multivariate analysis , psychiatry , sleep quality , pathology , environmental health , computer science , operating system
Background Growing evidence suggest that sleep disturbance is a risk factor for Alzheimer’s disease, but the relationship between sleep disturbance and cognitive impairment is not clear. Method This was a population‐based cross‐sectional study. A total of 1649 participants from a village in the suburbs of Xi’an, China were enrolled from January 3 to March 26, 2017. Sleep quality was assessed using the Pittsburgh sleep quality index (PSQI). Cognitive function was assessed with the mini‐mental state examination (MMSE). Univariate and multivariate analyses were used to analyze the relationships between sleep disturbance and cognitive impairment. Result Among 1649 subjects,110(6.7%) were diagnosed as cognitive impairment, and 960(58.2%) were diagnosed as sleep disturbance. In bivariate analysis, cognitive impairment was associated with insomnia)ρ=0.110; 95%CI=0.060‐0.154 ; P<0.01(, sleep efficiency)ρ=‐0.152; 95%CI=‐0.196‐ ‐0.105; P<0.01(, age)ρ=0.237; 95%CI=0.195‐0.279; P<0.01(and educational level )ρ=‐0.190; 95%CI=‐0.229‐ ‐0.149; P<0.01(. In the binary logistic regression, cognitive impairment was positively associated with the scales of PQSI (OR=1.072; 95%CI=1.016‐1.130; P=0.012). In the internal constitution of PQSI, cognitive impairment was positively associated with the sleep duration (OR=1.567; 95% CI=1.242‐1.979; P<0.01), step disturbances (OR=0.003; 95%CI=0.000‐0.023; P=0.017), and negatively associated with the habitual sleep efficiency (OR=1.068; 95%CI=1.012‐1.127; P<0.01). Cognitive impairment also was negatively associated with patients age (OR=0.130; 95%CI=0.069‐0.244; P<0.01). Conclusion Sleep disturbances is associated with cognitive impairment. However, the causal relationships between sleep disturbances and cognitive impairment are not clear and need to be further studied.