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Metabolic syndrome and successful aging: A six‐year cohort study TIGER among community‐dwelling elderly in Taiwan
Author(s) -
Lin YiHsuan,
Chen YenChing,
Chiou JengMin,
Chen TaFu,
Lai LiangChuan,
Chen JenHan
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.038052
Subject(s) - medicine , gerontology , depression (economics) , activities of daily living , cohort , metabolic equivalent , cohort study , prospective cohort study , metabolic syndrome , epidemiology , demography , physical therapy , physical activity , obesity , economics , macroeconomics , sociology
Background Metabolic syndrome (MetS) has known to be associated with disability 1, 2 , cognitive impairment 3 and depression 4 in the older adults. However, the association between MetS and successful aging, an overall assessment of elders’ status, is unknown. Method This study is part of an ongoing prospective cohort study: Taiwan Initiatives for Geriatric Epidemiological Research (TIGER). A total of 605 participants (age 65+) were recruited at baseline (2011‐2013) with 4‐year and 6‐year follow‐ups. After exclusion of participants with missing data of successful aging and metabolic syndrome as well as loss to follow‐up, a total of 202 participants were included for statistical analysis. MetS was assessed at baseline (2011‐2013). Successful aging was evaluated at baseline, 4‐year and 6‐year follow ups. Successful aging was defined by the following variables: cognitive function, numbers of chronic disease, activity of daily living (ADL), instrumental activities of daily living (IADL), gait speed, depression, self‐rated health, the frequency of participating in social and leisure activities, the family support and annual disposable income. Generalized linear mixed‐effects models with random intercept were utilized to assess the association between MetS and successful aging adjusting for time (follow‐up years), age, sex, years of education, smoking, alcohol consumption and the interaction terms with time. A p value of <0.05 (two‐tailed) for individual covariate and <0.1 for interaction with time was considered statistically significant. Results At baseline, 33.7% (n=68) older adults had MetS. Compared with older adults without MetS, those with MetS had lower diet quality (the modified Alternative Healthy Eating Index: 34.8 vs . 38.2), higher body mass index (25.7 vs . 22.9 kg/m 2 ), higher mean serum C‐reactive protein level (0.26 vs . 0.17 mg/dL), and more chronic diseases [e.g., hypertension (70.6% vs . 30.6%), diabetes mellitus (27.9% vs . 2.2%), hyperlipidemia (70.6% vs . 35.1%) and cardiac disease (29.4% vs . 15.7%)]. The baseline MetS had a negative effect on the probability of successful aging, and the effect increased as time elapsed [MetS×time interaction: odds ratio=0.87, 90% confidence interval=0.76‐0.98, p ‐value=0.06]. Conclusion MetS is a risk factor of successful aging for community‐dwelling older adults. Prevention of MetS in earlier life will be beneficial to successful aging in their later life.