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Development of a method of low‐intensity transcranial magnetic stimulation based on the resonance of neurotransmitters
Author(s) -
Novikov Vadim V,
Bobkova Natalia V,
Fesenko Evgeny E
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.037460
Subject(s) - stimulation , nuclear magnetic resonance , in vivo , materials science , chemistry , medicine , physics , biology , microbiology and biotechnology
Background In this work the effect of the weak combined magnetic fields (MFs) was studied in vivo in heritable animal model of AD: well characterized mice transgenic for mutant APPswe and mutant presenilin 1 (PS1dE9) that cause early onset familial Alzheimer’s disease (AD). Method Transgenic mice (Tg) and control C3H mice were exposed to the same MF at age of 8 months. Mice were also exposed by MF in two groups at the same time (Tg+MF and C3H+MF). Setups for generating a magnetic field inside the head were equipped with portable inductors that were mounted on the body. A direct current was supplied to generate a constant component of MFs with induction of 42 mcT. An alternating current signal produced by a programmable sinusoidal current generator was fed to create a variable component of MFs with induction of the amplitude of 80 nT. The current signal was the sum of frequencies in the range 4.0 ‐ 5.0 Hz. These frequencies correspond to the cyclotron frequencies of glutamic and aspartic acids as well as acetylcholine. After exposure to the MFs, the mice were trained in a Morris water maze for 18 days (four trials per day). Spatial memory was tested on the following day after completion of training with the hidden platform removed. During the test period (60 s), occupancy time spent in each sector was recorded. Result The MFs improved the memory in Tg animals. The results of the factor analysis demonstrate that factors of the sector preference became statistically significant for Tg groups after MFs exposure. Conclusion Thus, the data suggest that MFs can be applied for preventive purposes in a group of risk of AD.