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Clinical correlation of cerebrospinal fluid total tau levels and depression as measured by PHQ9 total in a memory clinic
Author(s) -
Pillai Malavika,
Nair Anil
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1002/alz.036853
Subject(s) - medicine , depression (economics) , cerebrospinal fluid , dementia , lumbar puncture , multivariate analysis , multivariate statistics , correlation , psychiatry , clinical psychology , disease , statistics , geometry , mathematics , economics , macroeconomics
Background Tau protein levels in cerebrospinal fluid is indicative of Alzheimer's dementia. We correlated PHQ‐9 screen severity of depression to CSF tau levels in a memory clinic sample. Method We analyzed data from patients attending a memory clinic in the south shore of Boston from 2010 to 2019 who had a lumbar puncture to obtain CSF tau levels. We correlated depression screening data from PHQ9 scores. Univariate analyses used Spearman correlation. A multivariate regression model was created including covariates of age, sex, and race. Results Depression as measured by PHQ9 total was not correlated to total tau levels in CSF. Conclusion In a memory clinic sample, CSF tau levels did not correlate to PHQ9 scores.