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Chronic rhinosinusitis precipitated by tumor necrosis factor alpha inhibitors is the phenotype of chronic rhinosinusitis without nasal polyps
Author(s) -
Papagiannopoulos Peter,
Devins Kyle,
Tong Charles Ching Lick,
Yver Christina,
Patel Neil N.,
Kuhar Hannah N.,
Bosso John V.,
Kohanski Michael A.,
Tajudeen Bobby A.,
Kuan Edward C.,
Batra Pete S.,
Cohen Noam A.,
Kennedy David W.,
Palmer James N.,
Montone Kathy,
Adappa Nithin D.
Publication year - 2020
Publication title -
international forum of allergy and rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.503
H-Index - 46
eISSN - 2042-6984
pISSN - 2042-6976
DOI - 10.1002/alr.22462
Subject(s) - medicine , nasal polyps , histopathology , gastroenterology , chronic rhinosinusitis , fibrosis , context (archaeology) , eosinophil , tumor necrosis factor alpha , sinusitis , edema , pathology , immunology , asthma , paleontology , biology
Background Chronic rhinosinusitis (CRS) is a frequently observed condition in patients with immunodeficiency secondary to tumor necrosis factor alpha inhibitors (TNFαis). The histologic features of CRS caused by TNFαis have yet to be determined and may have important implications in understanding the pathophysiology of the disease process. Methods A structured histopathology report was used to analyze sinus tissue removed during functional endoscopic sinus surgery (FESS). These structured histopathology variables were compared among patients with CRS on TNFαi (CRSαi), CRS without nasal polyps (CRSsNP) patients, and CRS with nasal polyps (CRSwNP) patients. Results Eighteen CRSαi, 91 CRSwNP, and 113 CRSsNP patients undergoing FESS were analyzed. Compared to CRSsNP, CRSαi patients exhibited increased mucosal ulceration (16.7% vs 0.9%, p  < 0.008), increased fibrosis (100% vs 34.5%, p  < 0.001), and increased presence of Charcot‐Leiden crystals (16.7% vs 0%, p < 0.002). Compared to CRSwNP, CRSαi patients demonstrated increased fibrosis (100% vs 54.9%, p  < 0.001), decreased presence of subepithelial edema (44.4% vs 69.2% p  < 0.043), decreased eosinophil aggregates (22.2% vs 47.3% p < 0.042), and fewer eosinophils per high‐power field (44.4% vs 73.6%, p  < 0.017). Conclusion CRSαi exhibits structured histopathology more similar to CRSsNP. In the appropriate clinical context, it may be reasonable that the medical regimen for these patients be focused on a more antineutrophilic, macrolide‐based approach. This study provides insight into the inflammatory environment of patients with CRSαi and may have implications for disease management.

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