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HLA‐II genes are associated with outcomes of specific immunotherapy for allergic rhinitis
Author(s) -
Zhao Yanming,
Zhao Yali,
Zhang Yuan,
Zhang Luo
Publication year - 2019
Publication title -
international forum of allergy and rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.503
H-Index - 46
eISSN - 2042-6984
pISSN - 2042-6976
DOI - 10.1002/alr.22384
Subject(s) - medicine , hla drb1 , itching , genotyping , immunology , allergy , genotype , human leukocyte antigen , gene , genetics , antigen , biology
Background Although the precise mechanisms underlying the efficacy of allergen‐specific immunotherapy (AIT) are not clear, some evidence suggests that this may be linked to polymorphisms in HLA‐II gene. We aimed to investigate the correlation between HLA‐II gene polymorphisms and house dust mite (HDM)‐specific immunotherapy efficacy, and evaluate specific polymorphisms as potential biomarkers in allergic rhinitis (AR) patients who would benefit most from AIT. Methods Fifty‐one Han Chinese patients with AR receiving HDM AIT were recruited. Genomic DNA was extracted from venous blood samples and genotyped for HLA‐DRB1 and HAL‐DQB1 alleles using the polymerase chain reaction sequence‐based genotyping method. Nasal and eye symptoms were investigated based on visual analogue scale and rhinoconjunctivitis quality of life. Results Allele DRB1*04:06; DRB1*14:05 showed a positive correlation with improvements in nasal blockage, nasal itching, eye itching, and activities. Similarly, DQB1*03:02:01; DQB1*05:03: 01 was positively correlated with improvements in nose blocking, nasal itching, eye itching, behavioral problems, and nasal symptoms scores; and DRB1*03:01; DRB1*04:06 positively correlated with nasal symptoms scores. In contrast, DRB1*07:01:01; DRB1*11:01 was negatively correlated with non‐pollen symptoms, behavioral problems, and nasal symptoms. Conclusion HLA‐DRB1 and HLA‐DQB1 gene polymorphism are associated with AIT efficacy in HDM‐sensitive Chinese patients with AR, of which DRB1*03:01; DRB1*04:06 and DQB1*03:02:01; DQB1*05:03:01 may be useful biomarkers of AR patient candidacy for effective AIT.