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Association between chronic rhinosinusitis and osteoporosis: a case‐control study using a national sample cohort
Author(s) -
Choi Hyo Geun,
Kong Gyu
Publication year - 2019
Publication title -
international forum of allergy and rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.503
H-Index - 46
eISSN - 2042-6984
pISSN - 2042-6976
DOI - 10.1002/alr.22365
Subject(s) - medicine , osteoporosis , odds ratio , nasal polyps , confidence interval , cohort , diabetes mellitus , dyslipidemia , population , hazard ratio , demography , pediatrics , endocrinology , obesity , environmental health , sociology
Background The purpose of this study was to further clarify the relationship between chronic rhinosinusitis (CRS) and osteoporosis in a Korean population. Methods The Korean National Health Insurance Service‒National Sample Cohort, with subjects ≥50 years old, was assessed for the time period 2002‐2013. In total, 68,459 osteoporosis participants were matched with 68,459 control participants at a ratio of 1:1 with respect to age, sex, income group, region of residence, hypertension, diabetes, and dyslipidemia. We analyzed previous histories of CRS with/without nasal polyp in the osteoporosis and control groups. CRS and osteoporosis were included using codes from the International Classification of Diseases―tenth edition and claim codes. Crude and adjusted odds ratios (ORs) were analyzed using conditional logistic regression analyses. The 95% confidence intervals (CIs) were then calculated. Subgroup analyses were performed according to age and sex. Results The rate of CRS with/without nasal polyp was higher in the osteoporosis group (3.0% [2078 of 68,459]) compared with the control group (2.0% [1344 of 68,459]) ( p < 0.001). The adjusted OR of CRS with/without nasal polyp was 1.47 (95% CI, 1.37‐1.58; p < 0.001) in the osteoporosis group. The results of the subgroup analyses were consistent. Conclusion The ORs of CRS were increased in osteoporosis participants. This relation was consistent in all age and sex groups.