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B cell lymphoma‐2‐like protein‐12 association with T‐helper 2 inflammation in chronic rhinosinusitis with allergy
Author(s) -
An YunFang,
Wu YongJin,
Zeng XianHai,
Song LiJuan,
Ma Fei,
Liao WenJing,
Liu ZhiQiang,
Yang Gui,
Zhang XiaoWen,
Liu ZhiGang,
Zhao ChangQing,
Yang PingChang
Publication year - 2018
Publication title -
international forum of allergy and rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.503
H-Index - 46
eISSN - 2042-6984
pISSN - 2042-6976
DOI - 10.1002/alr.22223
Subject(s) - medicine , immunology , pathogenesis , allergy , immunoglobulin e , mucous membrane of nose , immune system , lymphoma , cytokine , antibody
Background T‐helper 2 (Th2) polarization plays a critical role in the pathogenesis of chronic rhinosinusitis (CRS) with accompanying nasal allergy. Recent studies indicate that B cell lymphoma‐2‐like protein‐12 (Bcl2L12) is associated with immune dysregulation. The purpose of this study was to elucidate the role of Bcl2L12 in the pathogenesis of Th2 polarization of CRS patients. Methods CRS patients with nasal allergy (CRSa) and without nasal allergy (CRSna) were recruited into this study. CD4 + T cells were isolated from the blood samples of human subjects. A variety of immunologic molecular strategies were used to assess Th2 polarization and Bcl2L12 expression. Results Twenty CRSa patients, 20 CRSna patients, and 20 healthy subjects were recruited into this study. High levels of immunoglobulin E (IgE), interleukin 4 (IL‐4), IL‐5, IL‐13, and Bcl2L12 were detected in nasal extracts of CRSa patients, but not in CRSna patients. The levels of Bcl2L12 were positively correlated with Th2 cytokines. CD4 + T cells from CRSa patients were prone to differentiate into Th2 cells, in which Bcl2L12 was required. Conclusion Bcl2L12 is positively correlated with Th2 cytokine levels in the nasal mucosa of CRSa patients. Bcl2L12 contributes to the Th2 polarization, which may be a novel therapeutic target in the treatment of CRSa.