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Adoptive cell therapy of tolerogenic dendritic cells as inducer of regulatory T cells in allergic rhinitis
Author(s) -
Sun Wei,
Wei JiaWei,
Li Hang,
Wei FanQin,
Li Jian,
Wen WeiPing
Publication year - 2018
Publication title -
international forum of allergy and rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.503
H-Index - 46
eISSN - 2042-6984
pISSN - 2042-6976
DOI - 10.1002/alr.22217
Subject(s) - medicine , adoptive cell transfer , immunology , il 2 receptor , immunotherapy , effector , dendritic cell , regulatory t cell , in vitro , peripheral tolerance , immune system , t cell , biology , biochemistry
Background Regulatory T cells (Tregs) have become promising candidates for immunotherapy in allergic rhinitis (AR). The contributing role of tolerogenic dendritic cells (tDCs) in the augmentation of Tregs in AR remains to be determined. Methods The properties of tDCs in expanding Tregs and their potential to ameliorate AR were evaluated in vitro and in vivo. Results Monocyte‐derived tDCs stimulated with Dermatophagoides pteronyssinus allergen 1 favored the generation of activated Tregs (aTregs) and suppressed effector T‐cell responses in a transforming growth factor‐beta/interleukin‐10 (TGF‐β/IL‐10)‐dependent manner in vitro. The adoptive transfer of tDCs inhibited allergic airway inflammation in the mouse model, whereas depletion of CD25 + cells or blocking TGF‐β/IL‐10 signaling eliminated the inhibitory effect, indicating that Tregs were involved in the anti‐inflammatory activity of tDCs. Conclusion Our data show that tDCs are a potential therapeutic target in AR.