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Effects of mometasone furoate–impregnated biodegradable nasal dressing on endoscopic appearance in healing process following endoscopic sinus surgery: a randomized, double‐blind, placebo‐controlled study
Author(s) -
Zhao KeQing,
Yu YiQun,
Yu HongMeng
Publication year - 2018
Publication title -
international forum of allergy and rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.503
H-Index - 46
eISSN - 2042-6984
pISSN - 2042-6976
DOI - 10.1002/alr.22213
Subject(s) - medicine , mometasone furoate , perioperative , surgery , saline , placebo , randomized controlled trial , anesthesia , endoscopy , nasal polyps , endoscopic sinus surgery , nasal administration , corticosteroid , alternative medicine , pathology , immunology
Background Postoperative care is an important factor affecting the outcome of endoscopic sinus surgery (ESS) in patients with chronic rhinosinusitis (CRS). The aim of this study was to test the effect of mometasone furoate (MF)‐soaked biodegradable nasal dressings (BNDs) on endoscopic appearance in CRS patients with nasal polyps (CRSwNP) after ESS. Methods This study was a prospective, randomized, double‐blinded, placebo‐controlled study. A total of 64 CRSwNP patients with bilateral ESS were enrolled and randomly given 4 mL or 8 mL of MF‐soaked BNDs (NasoPore) in 1 nasal cavity and the same amount of normal saline‐soaked BNDs in the contralateral side. The BNDs were removed on the 7th or 14th postoperative day. Perioperative sinus endoscopy (POSE) and Lund‐Kennedy scores were collected, on the 7th or 14th postoperative days and at 1, 2, and 3 postoperative months. Results The POSE and Lund‐Kennedy scores showed that in the 4‐mL, 1‐week group, no significant differences between the sides treated with MF‐soaked BNDs and the normal saline‐soaked control were observed at any postoperative visits. In the 4‐mL, 2‐week group, significant differences were found at the 2‐week and 1‐month postoperative visits but not at the 2‐month and 3‐month visits. In the 8‐mL, 1‐week group, significant differences were found at the 1‐week, 1‐month, and 2‐month postoperative visits but not at the 3‐month visit. In the 8‐mL, 2‐week group, significant differences were found at all postoperative visits. Conclusion This study reveals that MF‐impregnated BNDs improve the endoscopic appearance in the healing process of CRSwNP after ESS.