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Clinical characteristics and prognostic factors of sinonasal undifferentiated carcinoma: a multicenter study
Author(s) -
Bonnecaze Guillaume,
Verillaud Benjamin,
Chaltiel Leonor,
Fierens Sylvestre,
Chapelier Mark,
Rumeau Cécile,
Malard Olivier,
Gavid Marie,
Dufour Xavier,
Righini Christian,
Urocoste Emmanuelle,
Rives Michel,
Bach Christine,
Baujat Bertrand,
Janot François,
Gabory Ludovic,
Vergez Sebastien
Publication year - 2018
Publication title -
international forum of allergy and rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.503
H-Index - 46
eISSN - 2042-6984
pISSN - 2042-6976
DOI - 10.1002/alr.22143
Subject(s) - medicine , oncology , radiation therapy , induction chemotherapy , multivariate analysis , stage (stratigraphy) , chemotherapy , hazard ratio , univariate analysis , lymph node , multicenter study , randomized controlled trial , confidence interval , paleontology , biology
Background Sinonasal undifferentiated carcinoma (SNUC) is a very rare entity with a poor prognosis. Due to the lack of studies on the subject, evidence is lacking concerning its management. Methods A multicenter collaborative study was conducted to assess treatment strategy, oncological outcome, and prognostic factors. Results Definitive analyses focused on 54 patients with a majority of advanced stage; the 3‐year overall survival (OS) and 3‐year recurrence‐free survival (RFS) rates were, respectively, 62.4% and 47.8%. During the follow‐up, 18 patients (33.3%) died, 10 (18.5%) developed metastases, 7 had lymph‐node involvement (13%), and 12 (22.2%) showed recurrence or local progression. In univariate analyses, treatment modalities associated with improved RFS were induction chemotherapy ( p = 0.02) and intensity‐modulated radiotherapy ( p = 0.007). In the multivariate analyses, only induction chemotherapy ( p = 0.047, hazard ratio [HR] = 0.39) was significantly associated with improved RFS. Conclusion Multimodal therapies including induction chemotherapy and intensity‐modulated radiotherapy may improve the prognosis of SNUC; surgery might improve local control. Further multicenter studies are required.