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Single vs multiallergen sublingual immunotherapy in the polysensitized patient: a pilot study
Author(s) -
Ortiz Alexandra Shams,
McMains K. Christopher,
Laury Adrienne M.
Publication year - 2018
Publication title -
international forum of allergy and rhinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.503
H-Index - 46
eISSN - 2042-6984
pISSN - 2042-6976
DOI - 10.1002/alr.22071
Subject(s) - medicine , slit , sublingual immunotherapy , allergen , allergy , allergen immunotherapy , vial , regimen , immunology , dermatology , chemistry , biology , genetics
Background Sublingual immunotherapy (SLIT) has emerged as an effective and exceptionally safe method of treatment of the atopic patient. However, the optimal number of allergens that should be included in the SLIT treatment regimen for the polysensitized patient is not known and practices vary widely. This study aims to compare the efficacy of single‐allergen SLIT with pauci‐allergen vs multiallergen aqueous SLIT in polysensitized patients. Methods Sixteen subjects sensitized to 6+ allergens were enrolled in the study. Subjects were blinded and randomized to SLIT treatment groups that included 1 (single), 3 (pauci), or all sensitized allergens (multi). Allergens selected were those to which the patient was most sensitized and correlated with history. Primary outcomes included daily allergy medication use, weekly Rhinoconjunctivitis Symptom Score (RCSS), and the mini–Rhinoconjuncitivitis Quality of Life Questionnaire (m‐RQLQ). All metrics were measured at baseline, 6 weeks, 3 months, 6 months, and 9 months. Results There were significant decreases from baseline in RCSS and m‐RQLQ scores in all study groups at each interval after beginning SLIT ( p < 0.05). There was no significant decrease in number of daily allergy medications used regardless of number of allergens in patient's treatment vial ( p = 0.50). No significant differences emerged based on number of allergens used. Conclusion Single‐antigen, pauci‐antigen, and multiantigen aqueous SLIT significantly improved allergy symptoms. There was no significant difference observed in efficacy of single‐allergen SLIT vs pauci‐allergen or multi‐allergen SLIT in polysensitized patients.